TABLE 1

Pancreas transcripts downregulated in Ngn3−/− mice

Gene ontology term (biological process)E12.5 threefold downE15.5 threefold downE18.5 threefold down
Regulation of cellular processAtrx, Sfpq, Braf, Nrip1, Zfp458, Rest, Klf7, Neurod1, Zfp398, Cpsf6, Nfia, Zfp192, Ncoa7, Crim1, Meis1, Mbtps1, Hnrpab, Hdac2, Zfp207, Gas2l3, Fubp1, Onecut2, Ercc6, Rbm5, Rapgef5, Arid5b, D030022P06Rik, Gna13, Shprh, Scmh1, Foxp2, and Paip1Pax6, Neurod1, Fev, St18, Neurog3, Isl1, and Ins2Pitx2, Fgd4, Nr3c2, Rapgef1, Rcor2, Il2, Gtf2i, Zfpm2, Stk36, Jarid1d, Inpp5d, Elavl1, E130112L23Rik, Rasgrf1, Zfp580, Zw10, Dnmt3a, Igfbp1, Cideb, Pax6, Rora, Spock2, Gtf3c1, Mlxipl, Nr2f2, Ins2, Tcfec, Malt1, Hcfc1, Neurod1, Igsf1, Itsn1, Ikzf1, Grm2, Isl1, Apoa2, Cables1, Mapk8ip2, Smurf1, Hipk1, Rps6ka5, Sim1, A230083H22Rik, Psd, Gli3, Nf1, Khdrbs3, Klf9, Braf, Pknox2, Tgfbr1, Gata1, Etv1, Smarca2, Bcl2l2, Ahsg, Dlg5, Ptpn11, Eda, Iqgap1, Pde6h, Brdt, Adam10, C030010B13Rik, Gatad2b, Mmp9, Ccnc, Cacna1a, Mecp2, Pde6g, Zdhhc17, Mafb, Ighmbp2, Creb1, Cdc37l1, Edg2, Pdlim1, Lst1, Calcoco1, Nkx6-1, AI324046, BC031441, Rph3al, Pias1, Tcf7l2, Sox13, St18, Frzb, Sebox, Ciapin1, Eef1a2, Rbx1, Batf, Fgf9, Ccna1, Dhcr24, Nono, Foxn4, and Hoxd3
TransportAbcb10, Huwe1, Colec10, Mbtps1, Atp8a1, Gcg, Napg, Exoc5, and Kif23Gcg, Ghrl, Cadps, Syt13, Slc7a14, Ins1, Ins2, and Sytl4Kif3b, Fabp1, Col4a6, Atp6v0a1, Kcnn2, Atp2a3, Fndc5, Atp11c, Syt13, Ins1, Zw10, Atp6v1g2, Snap25, Ghrl, Timm22, Atp1b1, Slc4a1, Uqcrq, Scn4a, Cadps, Lrp11, Fars2, Slc30a8, Laptm5, Aplp1, Ins2, Snx26, Slc2a5, Itpr2, Malt1, Sv2b, Slc9a1, Sytl4, Itsn1, Grm2, Apoa2, Slco2b1, Slc16a9, Rab23, Rab21, Rab37, Camk2b, Anxa6, Slc16a10, Ahsg, Stxbp1, Uty, Ptpn11, Eda, Apoa1, Brdt, Slc7a14, Adam10, 1300017J02Rik, Col11a2, Ap3m2, Lin7b, Cacna1a, Gcg, Zdhhc17, Prkcb1, Kif13a, AI324046, Thoc4, Abcc8, Rph3al, Igf2r, Mon1b, Ap4b1, Afp, Slc35a5, Syt7, Trpm5, Scnn1b, Fgf9, Slc39a2, Foxn4, and Scg5
System developmentAtrx, Mtss1, Nrip1, Neurod1, Cxadr, Ppp3cb, Mbp, Rapgef5, and Gna13Pax6, Neurod1, Neurog3, Isl1, and Insm1Pitx2, Casq2, Pip5k1c, Rapgef1, Il2, Atp6v0a1, Inpp5d, Crybb1, Crybb3, Pax6, Spock2, Chrdl1, Nr2f2, Aplp1, Tnfaip2, Neurod1, Ikzf1, Isl1, Apoa2, Robo1, Cables1, Smurf1, Sim1, Rab23, Papss2, Gli3, Nf1, Hsd11b1, Scube1, Tgfbr1, Add2, Etv1, Arts1, Ahsg, Stxbp1, Ptpn11, Eda, Apoa1, Tmprss6, Mmp9, Mecp2, Tnfrsf11a, Ankrd17, Mafb, Creb1, Lst1, Ptprj, Nkx6-1, Epm2a, Mepe, Insm1, Afp, Ciapin1, Efnb2, Fgf9, Dhcr24, Lor, Slitrk6, Foxn4, and Hoxd3
Cellular biosynthetic processGch1, St8sia3, Galnt7, Etnk1, Zdhhc2, and Paip1Gch1Gch1, Inpp5d, Fut10, Atp6v1g2, Fars2, Apoa2, Pank2, Zdhhc2, St8sia5, Mecr, Pigx, Zdhhc17, Dct, Nmt2, Dio2, Eif2s3, Eef1a2, Cps1, Umps, and Foxn4
Cell cycle processBub3, Gas2l3, and Rbm50Zw10, Hcfc1, Cables1, A230083H22Rik, Camk2b, Ptpn11, Ccnc, Cdc37l1, Suv39h2, Rbx1, Fgf9, and Ccna1
Cellular component organization and biogenesisMtss1, Bub3, Cbx5, Cxadr, Huwe1, Crim1, Mbtps1, Hdac2, Setd8, Pot1a, Napg, Gna13, Shprh, and Kif23Pax6, Cadps, 4930488E11Rik, and Sytl4Kif3b, Fgd4, Pip5k1c, Fndc5, Ush1c, Fmn2, Zw10, Dnmt3a, Igfbp1, Pax6, Rtel1, Timm22, Cadps, Lrp11, Aplp1, Malt1, Sytl4, Itsn1, Robo1, Rps6ka5, Fhod1, Etv1, Smarca2, Ahsg, Stxbp1, Ptpn11, Eda, Brdt, Adam10, 6330505N24Rik, Ap3m2, Tmsb10, Mecp2, Hist3h2a, Creb1, Lst1, Kif13a, AI324046, Thoc4, 4930488E11Rik, Rph3al, Ap4b1, Suv39h2, Hist3h2ba, Syt7, Fgf9, Dhcr24, Slitrk6, and Scg5