TABLE 2

Tight glucose control in 4-month diabetic rats normalizes the rate of body weight gain and GHb levels but only partially ameliorates tactile allodynia

Body wt (g)GHb (%)50% Withdrawal thresholds (g)
Normal/8 months535 ± 463.7 ± 0.113.80 ± 2.03
Poor glucose control–diabetic/8 months270 ± 28*9.5 ± 0.7*3.04 ± 0.9
Poor glucose control–diabetic/4 months (before insulin treatment)308 ± 399.9 ± 1.62.92 ± 0.89
Tight glucose control–diabetic/4 months (after insulin treatment)403 ± 444.9 ± 0.26.76 ± 1.46§
  • Data are means ± SD of 6–10 animals. Four-month diabetic rats (poor glucose control–diabetic/4 months) were either left untreated for an additional 4 months (poor glucose control–diabetic/8 months) or subjected to tight glucose control for 4 months (tight glucose control–diabetic/4 months). The presence of tactile allodynia was evaluated as indicated in the legend to Fig. 1.

  • *

    * Significantly different from normal rats at P < 0.01 (Student's t test).

  • Significantly different from poor glucose control–diabetic/4 months at P < 0.01 (paired Student's t test). Significantly different from

  • normal and

  • §

    § poor glucose control–diabetic/4 months at P < 0.01 (Kruskal-Wallis test, followed by Dunn's test).