TABLE 3

Effects of sulfasalazine and PJ34 on mechanical hyperalgesia in experimentally diabetic rats

Mechanical hyperalgesia withdrawal threshold (g)
6 months9 months
Normal218 ± 50198 ± 4
Diabetic71 ± 3*87 ± 7*
Diabetic + sulfasalazine111 ± 14*133 ± 34
Diabetic + PJ34ND63 ± 5*
  • Data are means ± SE of four to eight animals.

  • *

    * Significantly different from normal rats at P < 0.01 (ANOVA, followed by Dunnett's test). The statistical analysis showed no significant differences when comparing the diabetic + sulfasalazine or diabetic + PJ34 with the untreated diabetic rats; however, the diabetic + sulfasalazine withdrawal thresholds at 9 months were not significantly different than those in normal rats. ND, not determined.