TABLE 6

Sulfasalazine treatment increases inosine levels in sciatic nerve extracts of diabetic rats

RatsInosine (nmol/mg protein)
Normal3.92 ± 0.47
Diabetic3.98 ± 0.38
Sulfasalazine-treated diabetic5.25 ± 0.64*
  • Data are means ± SD of extracts from three to five animals analyzed by reverse-phase HPLC. Assays were performed 9 months after induction of experimental diabetes.

  • *

    * Significantly different from normal and diabetic rats at P < 0.05 (ANOVA, followed by Dunnett's test).