TABLE 1

Morphometric parameters in E18.5 wild-type and FASDEL fetuses after feeding either standard chow or HFD to dams during gestation

Parameters at E18.5Standard chow during gestation
HFD during gestation
Wild typeFASDELWild typeFASDEL
Islet number per mm20.28 ± 0.060.31 ± 0.090.29 ± 0.120.32 ± 0.14
Islet area (%)0.54 ± 0.091.04 ± 0.07*0.58 ± 0.100.80 ± 0.07
Insulin plus PCNA-positive cells (%)1.02 ± 0.222.14 ± 0.14*1.34 ± 0.171.67 ± 0.11
Insulin plus caspase-3–positive cells (%)4.70 ± 1.101.12 ± 0.18*4.50 ± 1.802.28 ± 0.14*
Insulin content (ng/mg pancreas)50.1 ± 5.773.4 ± 3.2*54.7 ± 3.862.8 ± 3.5
  • Data are means ± SE. Complete pancreas sections from 10 to 12 fetuses at E18.5 of each genotype were analyzed.

  • *

    * P < 0.05 vs. the corresponding wild-type control.

  • P < 0.05 vs. the FASDEL fetuses from standard chow–fed dams during gestation.