TABLE 1

Downregulated genes in reemerging B-cells compared with B-cells extracted from naïve normoglycemic or hyperglycemic NOD mice

SymbolNameFunctionProcessComponent
Acp2Acid phosphatase 2, lysosomalAcid phosphatase, hydrolaseLysosome organization and biogenesisLysosome
Amy2Amylase 2Amylase/hydrolaseMetabolic processExtracellular space
C1qbComplement component 1, β polypeptideComplement activation, immune responseCytoplasm, extracellular space
Ctrb1Chymotrypsinogen B1Chymotripsin, hydrolase/peptidaseDigestion/proteolysisExtracellular space
Dgat2Diacylglycerol O-acyltransferase 2Diacylglycerol O-acyltransferaseGlycerol/lipidic metabolic processEndoplasmic reticulum, membrane
Ela1Elastase 1Hydrolase/peptidaseProteolysis/digestionExtracellular space
Ela2Elastase 2Hydrolase/peptidaseLeukocyte migration, proteolysis, phagocytosisExtracellular space
FcnaFicolin AReceptor binding, sugar bindingSignal transduction, complement activationCytoplasm, extracellular space
Hebp1Heme-binding protein 1Heme bindingHeme metabolic process, chemotaxisCytoplasm, mitochondrion
Hmox1Heme oxygenase (decycling) 1Heme oxygenase, ion binding, oxidoreductaseHeme oxidation, immune response, stress responseMembrane, microsome
Hs3st2Heparan sulfateTransferaseBiological processGolgi apparatus, membrane
Igf1Insulin-like growth factor 1Growth factor, hormoneAntiapoptosis/metabolic process and cell growth, IGF pathwayExtracellular space
LyzsLysozimeHydrolaseCell wall catabolic process/cytolysis, host defenseExtracellular space
Nr1h3Nuclear receptor subfamily 1Transcription factor, steroid hormone receptorTranscriptionNucleus
PilrbPaired immunoglobin-like type 2 receptor β1Molecular functionBiological processMembrane
PpargPeroxisome proliferator–activated receptor γTranscription factor, receptor activity, metal ion bindingTranscription, inflammatory response, fat cell differentiationCytosol, nucleus
TgfbiTransforming growth factor, β inducedProtein bindingCell adhesionExtracellular space
Tgm1Transglutaminase 1Acyltransferase ion bindingMorphogenesis, peptide cross linking, protein metabolic processAdherens junction, membrane