TABLE 1

Echocardiographic evaluation of contractile function in wild-type and Akita mice at 20, 36, and 54 weeks of age

nFractional shortening (%)Ejection fraction (%)Heart rate (bpm)Stroke volume (μl/g body wt)Cardiac output (μl · min−1 · g−1 body wt)
Wild type (20 weeks)938.6 ± 2.476 ± 3415 ± 121.13 ± 0.03467 ± 14
Akita (20 weeks)738.7 ± 2.476 ± 3472 ± 311.12 ± 0.07527 ± 15*
Wild type (36 weeks)639.6 ± 1.278 ± 1470 ± 410.97 ± 0.04456 ± 25
Akita (36 weeks)539.7 ± 2.778 ± 3421 ± 291.13 ± 0.04*476 ± 33
Wild type (54 weeks)624.6 ± 1.957 ± 3523 ± 291.00 ± 0.10524 ± 28
Akita (54 weeks)627.6 ± 1.962 ± 3448 ± 280.95 ± 0.04426 ± 28*
  • Data are means ± SE unless otherwise indicated.

  • *

    * P < 0.05 vs. wild type.