TABLE 1

List of epidemiological, clinical, and biochemical parameters of the female LURIC participants on whom this study is based

ParameterType 2 diabetes, survivorsType 2 diabetes, deceasedCAD, no diabetes, survivorsNo CAD, no diabetes, survivorsP values (Kruskal-Walis/ANOVA)
n63632023
Age (years)65.74 ± 8.9466.33 ± 8.9968.33 ± 8.2165.97 ± 7.97Matching criteria
Type 2 diabetes*63 (100)63 (100)0 (0)0 (0)Selection criteria
Diabetes diet63 (100)63 (100)0 (0)0 (0)
Death0 (0)63 (100)0 (0)0 (0)Selection criteria
Active smoker8 (12.7)10 (15.9)2 (10)3 (13)
Hypertension63 (100)63 (100)12 (60)23 (100)Selection criterion
BMI (kg/m2)27.26 ± 4.1526.85 ± 4.3827.31 ± 4.2428.63 ± 4.900.42122
CHD43 (68.3)50 (79.4)0 (0)23 (100)Selection criterion
MI14 (22.2)31 (49.2)0 (0)14 (60.8)
Stroke5 (7.9)7 (11.1)1 (5)1 (4.3)
Dyslipidemia63 (100)63 (100)20 (95)23 (100)Selection criterion
A1C (%)6.43 ± 1.036.70 ± 1.705.74 ± 0.605.63 ± 0.530.02320
OAD6 (9.5)9 (14.3)0 (0)0 (0)Selection criterion
Insulin treatment4 (6.3)10 (15.9)0 (0)0 (0)Selection criterion
Creatinine (μmol/l)82 ± 2089 ± 5769 ± 8.872 ± 110.00020
Creatinine clearance (Cockroft-Gault formula)81.54 ± 24.8177.83 ± 29.2279.03 ± 17.1783.41 ± 25.310.59448
Creatinine clearance (MDRD-short formula)78.22 ± 17.8476.51 ± 22.2079.98 ± 12.0977.22 ± 14.580.93046
Clearance below 60 ml/min5 (7.9)10 (15.9)1 (5)3 (13)
Total cholesterol (mg/dl)209.27 ± 45.63206.90 ± 46.05244.30 ± 57.65224.54 ± 48.620.01976
Triglycerides (mg/dl)165.78 ± 78.42182.48 ± 132.40170.95 ± 115.87151.42 ± 46.020.90922
Fibrinogen (mg/dl)407.43 ± 116.5442.67 ± 114.57379.7 ± 113.56351.46 ± 63.150.00007
Interleukin-615.96 ± 8.8414.21 ± 14.21NDND
hsCRP10.75 ± 23.0812.37 ± 23.797.44 ± 15.543.84 ± 4.390.00763
  • Data are means ± SD or n (%) of patients.

  • *

    * Diabetes was defined according to World Health Organization/American Diabetes Association criteria; in all probands without known history of diabetes, diabetes was ruled out by an oral glucose tolerance test.

  • Hypertension defined by the use of antihypertensive drugs and/or systolic blood pressure >140 and/or diastolic blood pressure >90 mmHg.

  • Dyslipidemia defined by use of lipoid lowering drugs and/or HDL <35 mg/dl, triglycerides >170 mg/dl, and total cholesterol >240 mg/dl. CAD, angiographically proven coronary artery disease; MI, myocardial infarction; ND, not done; OAD, oral antidiabetic drug.