TABLE 2

Triglyceride concentrations according to genotype at GCKR rs780094* in 12 studies comprising 46,549 individuals

CountryStudyCC (mg/dl)CT (mg/dl)TT (mg/dl)Minor allele frequencyZ scoreP value
Finland and SwedenDGI*136 ± 89 (1,142)144 ± 103 (1,194)164 ± 114 (300)0.34−5.763.7 × 10−8
SwedenMDC-CC*117 ± 70 (2,207)123 ± 71 (2,457)128 ± 74 (639)0.35−5.451.7 × 10−7
SwedenMPP107 ± 70 (4,059)113 ± 77 (4,616)117 ± 72 (1,425)0.37−6.171.3 × 10−9
SwedenNORDIL151 ± 78 (2,223)157 ± 79 (2,220)172 ± 87 (572)0.34−6.147.4 × 10−9
SwedenSkania Diabetes 2000 Registry205 ± 148 (1,076)224 ± 97 (1,069)253 ± 104 (259)0.33−4.871.8 × 10−6
FinlandBotnia-PPP106 ± 58 (1,273)115 ± 69 (1,429)125 ± 69 (409)0.36−5.624.8 × 10−8
FinlandFINRISK128 ± 86 (3,009)130 ± 89 (3,398)142 ± 105 (931)0.36−5.008.0 × 10−7
SpainValencia108 ± 66 (446)112 ± 64 (792)118 ± 71 (370)0.48−2.260.02
U.S.Dallas Heart Study blacks103 ± 90 (1,163)108 ± 78 (444)110 ± 59 (44)0.16−2.530.01
U.S.Dallas Heart Study Hispanics149 ± 138 (244)151 ± 124 (263)161 ± 155 (58)0.34−0.560.29
U.S.Dallas Heart Study whites131 ± 115 (342)135 ± 97 (455)164 ± 124 (145)0.40−4.044.4 × 10−5
U.S.GOLDN109 ± 75 (378)143 ± 90 (538)133 ± 87 (146)0.39−2.240.03
U.S.BPRHS153 ± 104 (423)165 ± 92 (330)174 ± 118 (84)0.30−2.960.003
SingaporeSingapore NHS-98 Chinese112 ± 64 (842)120 ± 71 (1233)131 ± 82 (616)0.46−5.413.0 × 10−5
SingaporeSingapore NHS-98 Malays132 ± 75 (268)150 ± 91 (332)153 ± 97 (134)0.410.02
SingaporeSingapore NHS-98 Asian Indians140 ± 79 (332)151 ± 89 (188)163 ± 109 (28)0.220.08
Total n = 46,54919,42720,9586,164Meta-analysis P value 3 × 10−56
  • Data means ± SD (n) (continuous raw measures). Association analyses were conducted with an outcome variable of residual log- triglyceride concentration after adjustment for age, sex, and diabetes status. For ease of interpretation, unadjusted triglyceride concentrations are presented in the table. To convert the values to millimoles per liter, multiply triglycerides by 0.01129. All P values are two sided.

  • *

    * DGI and MDC-CC results have been reported in ref. 1. BPRHS, Boston Puerto Rican Health Study.