TABLE 1

Plasma and liver parameters of Ffar1+/+ and Ffar1−/− mice after 8 weeks on 10% low-fat diet and 58% high-fat diet

Low-fat diet
High-fat diet
P value
Ffar1+/+Ffar1−/−Ffar1+/+Ffar1−/−DietGenotype
n5555
Plasma glucose (mg/dl)227 ± 18236 ± 6236 ± 16230 ± 17NSNS
Plasma insulin (ng/ml)0.79 ± 0.181.76 ± 0.523.54 ± 1.133.78 ± 1.130.02NS
Plasma total cholesterol (mg/dl)108.6 ± 5.4124.8 ± 7.6138.5 ± 6.6139.1 ± 9.1<0.01NS
Plasma triglyceride (mg/dl)68.6 ± 4.548.1 ± 6.863.4 ± 5.855.6 ± 5.2NS0.02
Liver cholesterol ester (mg/g tissue)6.37 ± 0.638.34 ± 0.795.65 ± 0.436.06 ± 0.210.020.05
Liver triglyceride (mg/g tissue)62.2 ± 9.8122 ± 20226 ± 47301 ± 60NS<0.01
Liver free cholesterol (mg/g tissue)1.92 ± 0.101.64 ± 0.191.34 ± 0.131.71 ± 0.11NSNS
Liver weight (g)1.11 ± 0.071.54 ± 0.061.21 ± 0.061.33 ± 0.11NS0.02
Liver cholesterol ester (mg/liver)7.09 ± 0.8712.95 ± 1.616.74 ± 0.368.10 ± 0.860.02<0.01
Liver triglyceride (mg/liver)71.3 ± 15.9193 ± 39281 ± 72421 ± 104<0.01NS
Liver free cholesterol (mg/liver)2.10 ± 0.022.51 ± 0.251.59 ± 0.102.23 ± 0.140.02<0.01
  • Data are means ± SE. The P values are generated by two-way ANOVA testing diet and genotype effects.