TABLE 4

Association of three-marker haplotypes from haploblock 2 with traits of the metabolic syndrome in the replication study sample

Haplotype 122
Haplotype 121
Haplotype 112
PresentNot presentP valuePresentNot presentP valuePresentNot presentP value
n429601102928136894
Systolic blood pressure (mmHg)133.5 ± 16.8135.3 ± 17.5NS136 ± 17134.4 ± 17.3NS139 ± 18134 ± 170.04
Diastolic blood pressure (mmHg)80.4 ± 9.781.7 ± 9.9NS80 ± 881 ± 10NS82 ± 1281 ± 9NS
Hypertension (%)*40.643.4NS46.141.8NS47.841.4NS
BMI (kg/m2)26.7 ± 4.326.6 ± 4.1NS27.5 ± 4.226.6 ± 4.20.03727.3 ± 3.226.6 ± 4.3NS
Diabetes (%)*8.99.1NS19.87.90.000078.612.0NS
Triglycerides (mg/dl)133 ± 76140 ± 109NS145 ± 102136 ± 96NS175 ± 182131 ± 750.00008
HDL cholesterol (mg/dl)63 ± 1560 ± 150.00357 ± 1262 ± 150.00856 ± 1462 ± 150.00008
Factor score−0.66 ± 1.09−0.52 ± 1.15NS−0.12 ± 1.33−0.63 ± 1.090.002−0.32 ± 1.16−0.62 ± 1.120.044
  • Data are means ± SD unless otherwise indicated. Asymptotic P values are given.

  • *

    * Definitions are as defined in the text. The most frequent hapotype, haplotype 111, did not show any evidence of association with these phenotypes and is thus not shown in the Table. NS, not significant.