TABLE 4

Associations between rs9939609 genotypes and the risk of type 2 diabetes in men and women

DiabeticNondiabeticModel 1P valuesModel 2P valuesModel 3P values
Men (n = 2,287)
    TT362 (33.6)406 (33.5)1.01.0
    TA486 (45.2)556 (45.9)0.98 (0.81–1.18)0.830.95 (0.78–1.17)0.640.95 (0.78–1.16)0.64
    AA228 (21.2)249 (20.6)1.03 (0.82–1.29)0.820.94 (0.73–1.21)0.630.99 (0.78–1.26)0.94
Women (n = 3,520)
    TT484 (32.1)726 (36.0)1.01.01.0
    TA739 (49.1)944 (46.9)1.17 (1.01–1.36)0.0361.08 (0.92–1.27)0.331.21 (1.03–1.43)0.019
    AA283 (18.8)344 (17.1)1.24 (1.02–1.50)0.0341.02 (0.83–1.26)0.841.26 (1.03–1.56)0.029
  • Data are n (%) and OR (95% CI). Model 1, crude analysis; model 2, adjusted for BMI; model 3, adjusted for other covariates than BMI, including age, physical activity (quintiles), smoking (never, past, and current), alcohol intake (nondrinker and drinker [0.1–4.9, 5–10, or >10 g/day]), family history of diabetes, and menopausal status (pre- or postmenopausal [never, past, or current hormone use]; for women only).