Association of four SNPs in PCLO with type 2 diabetes in a case/control sample and development of type 2 diabetes in a population-based sample of Pima Indians

SNPRisk allele and frequencyEarly-onset type 2 diabetes in the case/control sample*
Development of type 2 diabetes in the population-based sample
Ala2742Thr (rs976714)Thr (A)0.0040.020.020.04
(G/A)0.501.83 (1.20–2.78)1.95 (1.09–3.52)1.12 (1.02–1.23)1.18 (1.00–1.38)
Val2413Ile (rs10954696)Ile (A)0.0090.030.050.06
(G/A)0.501.75 (1.15–2.67)1.96 (1.07–3.58)1.10 (1.00–1.21)1.17 (0.99–1.39)
(A/G)0.571.65 (1.13–2.42)1.95 (1.08–3.51)1.09 (1.00–1.19)1.11 (0.96–1.28)
(G/A)0.621.78 (1.19–2.65)2.02 (1.02–4.00)1.08 (0.99–1.17)1.10 (0.95–1.28)
  • Data are adjusted P value with OR (95% CI)* and adjusted P value with hazard ratio (95% CI)†. The case/control sample is composed of 895 Pima subjects, 300 case subjects with diabetes onset age <25 years, 334 nondiabetic control subjects age >45 years, and 261 additional sibs of either case or control group for within-family test. The population-based sample consists of 3,501 full-heritage Pima Indians and 1,561 diabetic and 1,940 nondiabetic subjects at the last visit. Most of the case/control subjects (n = 715) were included in the population-based sample.

  • *

    * In the case/control analysis, a logistic regression was used to adjust for sex, birth year, and family membership.

  • For the population based-sample, a survival analysis (Poisson model) was applied to adjust for sex, birth year, age of last visit, age of onset for diabetes, and family membership. All P values are for a recessive genetic model.