TABLE 2

SNPs in PCLO associated with type 2 diabetes in the WTCCC 500 K GWA and their corresponding associations in the DGI 500 K GWA, the DIAGRAM meta-analysis, and Pima Indians

SNPAlleles (1/2)WTCCC
DGI
DIAGRAM
Pima Indians
Case (f1)Control (f1)PaddCase (f1)Control (f1)PaddPaddCase (f1)Control (f1)PaddPrec
rs34608268A/C0.560.530.0040.530.510.16
rs2715148C/A0.520.490.020.500.490.320.0050.740.730.360.35
rs2888019C/T0.520.490.020.510.490.340.0030.750.700.070.15
rs1986742T/C0.520.500.020.500.490.330.004
rs9690648A/G0.920.940.020.950.960.170.010.880.850.090.10
rs7781142C/T0.540.520.060.530.510.320.0040.700.640.050.04
rs7799260C/G0.540.520.070.520.510.330.0050.700.640.050.04
rs7778238C/G0.510.490.060.520.510.190.002
  • The frequency of allele 1 (f1) for each SNP is given for case subjects (with type 2 diabetes) and control subjects in each individual population. Frequency information was not available for the DIAGRAM meta-analysis, which combined data from the WTCCC, DGI, and FUSION studies of subjects of European descent (ref. 20). Data for WTCCC was obtained from http://www.wtccc.org.uk/info/summary_stats.shtml. Data for DGI was obtained from http://www.broad.mit.edu/diabetes. P values are calculated by comparison of genotypes. P values for WTCCC, DGI, and DIAGRAM are given for an additive model (Padd). P values for the Pima Indians are given for both an additive (Padd) and a recessive model (Prec).