TABLE 1

Characteristics of subsets of full-heritage Pima Indians with measurements of energy expenditure and insulin action by the MC4R variant

24-h energy expenditureSleep energy expenditureRMRM-lowM-high
ControlNT100R165QControlNT100R165QControlNT100R165QControlNT100R165QControlNT100R165Q
n (M/F)245 (129/116)4 (1/3)3 (3/0)237 (122/115)4 (1/3)3 (3/0)356 (203/153)6 (5/1)2 (1/1)350 (192/158)3 (1/2)6 (5/1)314 (177/137)3 (1/2)5 (4/1)
Age (years)26.3 ± 6.621.2 ± 2.131.7 ± 6.126.2 ± 6.521.2 ± 2.131.7 ± 6.126.1 ± 6.027.9 ± 4.920.6 ± 2.726.2 ± 6.021.6 ± 2.527.9 ± 4.926.2 ± 6.121.6 ± 2.526.8 ± 4.6
Height (cm)166.0 ± 7.9167 ± 5.4175 ± 0.5*166.0 ± 7.9167.0 ± 5.4175 ± 0.5*166.1 ± 8.1168.3 ± 4.7161 ± 9.5165.8 ± 8.2161.4 ± 6.8168.3 ± 4.7166.0 ± 8.5161.4 ± 6.8168.6 ± 5.2
Weight (kg)92.9 ± 24.199.5 ± 7.4119.4 ± 21.1*93.3 ± 24.399.5 ± 7.4119.4 ± 21.194.0 ± 22.7103.3 ± 10.991.4 ± 7.295.0 ± 23.090.9 ± 5.2103.4 ± 10.994.0 ± 22.290.9 ± 5.2102.1 ± 11.7
BMI (kg/m²)33.7 ± 8.635.8 ± 4.738.7 ± 6.733.5 ± 8.635.8 ± 4.738.7 ± 6.734.0 ± 7.836.5 ± 4.035.0 ± 1.434.5 ± 7.734.9 ± 1.036.5 ± 4.034.0 ± 7.434.9 ± 1.035.9 ± 4.1
% Fat33.3 ± 9.036.2 ± 10.936.1 ± 5.733.5 ± 8.936.2 ± 10.936.1 ± 5.733.1 ± 8.732.7 ± 8.129.8 ± 12.833.8 ± 8.433.3 ± 10.932.7 ± 8.033.4 ± 8.433.3 ± 10.934.2 ± 8.0
FFM (kg)60.7 ± 12.463.2 ± 9.475.7 ± 9.7*60.8 ± 12.763.2 ± 9.475.7 ± 9.7*61.8 ± 12.469.4 ± 10.364.7 ± 16.862.0 ± 12.761.0 ± 13.569.4 ± 10.361.7 ± 12.661.0 ± 13.566.9 ± 9.3
Fat mass (kg)32.2 ± 14.836.4 ± 12.443.7 ± 13.032.4 ± 14.836.4 ± 12.443.7 ± 13.032.2 ± 13.733.9 ± 9.626.7 ± 9.633.1 ± 13.629.9 ± 8.734.0 ± 9.632.3 ± 13.129.9 ± 8.735.2 ± 10.2
Fasting plasma glucose (mmol/l)4.88 ± 0.554.78 ± 0.434.55 ± 0.614.94 ± 0.554.78 ± 0.434.55 ± 0.615.00 ± 0.555.03 ± 0.214.75 ± 0.825.00 ± 0.555.04 ± 0.775.03 ± 0.214.98 ± 0.545.04 ± 0.774.98 ± 0.21
2-h plasma glucose (mmol/l)6.72 ± 1.676.69 ± 2.495.11 ± 1.126.72 ± 1.676.69 ± 2.495.11 ± 1.126.89 ± 1.726.90 ± 1.275.39 ± 2.286.94 ± 1.675.98 ± 1.916.90 ± 1.276.91 ± 1.715.98 ± 1.917.08 ± 1.34
  • Data are means ± SD. Control = neither variant; NT100 = A insertion variant; R165Q = G-to-A substitution.

  • * P < 0.05 for comparison of NT100 or R165Q to common variant using Wilcoxon's rank-sum test.