TABLE 3

Association of three-marker haplotypes from haploblock 2 with traits of the metabolic syndrome

Haplotype 122
Haplotype 121
Haplotype 112
PresentNot presentP valuePresentNot presentP valuePresentNot presentP value
n647769931,3231431,273
Hypertension traits
    Systolic blood pressure (mmHg)135 ± 21133 ± 19NS127 ± 18135 ± 200.0001128 ± 18135 ± 200.00008
    Diastolic blood pressure (mmHg)81 ± 1280 ± 12NS78 ± 1281 ± 120.03278 ± 1181 ± 120.0016
    Hypertension (%)*47.143.0NS23.746.40.0000132.246.40.001
Obesity traits
    BMI (kg/m2)26.8 ± 4.226.6 ± 4.1NS24.6 ± 3.626.9 ± 4.13.7 × 10−725.3 ± 3.826.9 ± 4.20.00002
    Waist circumference (cm)90 ± 1289 ± 13NS82 ± 1290 ± 123.2 × 10−885 ± 1290 ± 120.00001
    Obesity (%)*32.827.00.01912.930.80.000316.931.10.0005
Diabetes traits
    Diabetes (%)*9.36.60.0592.28.20.0416.58.0NS
    A1C (%)5.3 ± 0.95.2 ± 0.80.0125.1 ± 0.75.3 ± 0.90.00025.1 ± 0.65.3 ± 0.90.013
Dyslipidemia traits
    LDL cholesterol (mg/dl)147 ± 43142 ± 430.021135 ± 47145 ± 430.032130 ± 41146 ± 430.00002
    HDL cholesterol (mg/dl)54 ± 1654 ± 17NS56 ± 1954 ± 16NS53 ± 1854 ± 16NS
    Dyslipidemia (%)*30.427.9NS30.428.9NS33.128.6NS
Metabolic syndrome
    Factor score0.10 ± 1.23−0.11 ± 1.240.002−0.67 ± 1.000.04 ± 1.241.4 × 10−7−0.42 ± 1.280.03 ± 1.220.00005
    Three or more components* (%)16.010.50.0073.313.70.0028.613.5NS
  • Data are means ± SD.

  • *

    * Definitions are as defined in the text. NS, not significant.