TABLE 2

Characteristics of 22 SNPs genotyped in and around ADIPOQ in 2,543 men and women in the FOS

SNPPrevious name in the literatureLocation on chromosome 3 (NCBI 35)Relation to geneCall rateHWE P valueMajor alleleMinor alleleMAF
rs109372731880323975′ of promoter0.9510.013GA0.43
rs8642651880369945′ of promoter0.9670.071GT0.14
rs8223871880387395′ of promoter0.9950.816TC0.10
rs16861194−11426A/G188042127Promoter0.9910.290AG0.07
rs17300539−11391G/A188042162Promoter0.9840.816GA0.10
rs266729−11377C/G188042176Promoter0.9800.055CG0.27
rs182052188043484Intron 10.9930.0002GA0.33
rs822391188046505Intron 10.9630.686TC0.19
rs822396188049579Intron 10.9950.784AG0.19
rs12495941188050882Intron 10.9510.781GT0.35
rs7649121188051487Intron 10.9940.893AT0.19
rs17366568188053155Intron 10.9771.000GA0.11
rs2241766+45T/G188053594Exon 2 coding synonymous0.7480.182TG0.15
rs1501299+276G/T188053825Intron 20.7270.623GT0.26
rs3821799188054188Intron 20.9940.802CT0.46
rs3774262188054516Intron 20.9940.597GA0.14
rs17366743Y111H188054791Exon 3 coding nonsynonymous0.9961.000TC0.04
rs67739571880564073′UTR0.9880.796GA0.41
rs64441751880624463′ of 3′UTR0.9820.459GA0.27
rs130854991880635423′ of 3′UTR0.9820.933AG0.47
rs76286491880680833′ of 3′UTR0.9900.113CT0.14
rs173734141880682293′ of 3′UTR0.9790.186CT0.13
  • Call rate, success rate of genotyping each SNP in the FOS sample; HWE P value, Hardy-Weinberg equilibrium test P values, with significance set at ≤0.0001. MAF, MAF in the FOS, calculated from a subsample of 1,491 unrelated participants.