TABLE 4

Associations between the genotypes of the three SNPs and obesity or type 2 diabetes–related quantitative traits

rs8050136
rs9930609
rs9930506
CCCAAAPadditiveTTTAAAPadditiveAAAGGGPadditive
Obesity related*
    BMI (kg/m2)24.1 (0.1)24.2 (0.1)24.4 (0.5)0.3624.1 (0.1)24.3 (0.1)23.9 (0.5)0.7024.2 (0.1)24.1 (0.1)24.4 (0.3)0.74
    Waist circumference (cm)83.1 (0.2)83.6 (0.4)83.5 (1.4)0.2983.2 (0.2)83.6 (0.4)82.5 (1.5)0.4783.2 (0.2)83.2 (0.3)84.1 (1.0)0.68
    Body fat (%)26.4 ± 0.226.6 ± 0.327.0 ± 1.30.5826.4 ± 0.226.5 ± 0.427.2 ± 1.40.6426.4 ± 0.226.6 ± 0.326.4 ± 0.90.71
Type 2 diabetes related
    Glucose (mmol/l)5.63 ± 0.035.58 ± 0.055.58 ± 0.050.155.69 ± 0.035.62 ± 0.065.32 ± 0.230.075.70 ± 0.035.61 ± 0.045.50 ± 0.130.02
    A1C (%)5.85 ± 0.025.83 ± 0.035.74 ± 0.120.355.87 ± 0.025.83 ± 0.045.74 ± 0.150.175.88 ± 0.025.84 ± 0.035.75 ± 0.090.08
    Insulin (pmol/l)79.6 (0.8)78.0 (1.6)72.7 (5.2)0.1779.6 (0.8)77.4 (1.6)76.2 (6.0)0.2078.9 (0.9)79.8 (1.3)75.7 (3.6)0.98
    HOMA-B (%)103.4 (0.9)101.8 (1.8)104.4 (6.5)0.55103.2 (0.9)102.1 (1.8)108.7 (7.5)0.88102.5 (1.0)109.2 (1.5)102.2 (4.3)0.41
    HOMA-S (%)65.7 (0.6)68.1 (1.3)73.1 (5.0)0.0365.7 (0.6)68.7 (1.3)69.9 (5.3)0.0366.1 (0.7)66.4 (1.0)71.4 (3.3)0.28
  • Data are geometric means (SE) or means ± SE unless otherwise indicated.

  • *

    * Adjusted for age, sex, and region;

  • Assessed using dual-energy X-ray absorptiometry in a subpopulation comprising 1,139 participants (42% male) from Shanghai.

  • Adjusted for age, sex, region, and BMI; participants receiving anti-glucose treatment (n = 232) were excluded from the analyses.