TABLE 1

Initial clearance of glucose (K1glc), net clearance of glucose (Kglc), and lumped constant (LC) during GLP-1 and placebo infusion

K1glc (ml/100 cm3 per min)
Kglc (ml/100 cm3 per min)
LC
PlaceboGLP-1PPlaceboGLP-1PlaceboGLP-1
Grey matter20 (16–25)15 (13–18)0.078.0(6.5–9.8)6.8(5.5–8.3)0.55 (0.52–0.58)0.59 (0.56–0.62)
Cerebral cortex20 (16–24)15 (12–18)0.088.2(6.6–10.0)6.9(5.6–8.6)0.56 (0.53–0.59)0.60 (0.57–0.64)
Thalamus22 (18–28)16 (14–19)0.077.9(6.4–9.7)6.8(5.5–8.4)0.53 (0.50–0.55)0.57 (0.54–0.60)
Striatum20 (16–25)15 (13–18)0.088.5(6.9–10.5)7.2(5.9–8.9)0.57 (0.54–0.60)0.61 (0.57–0.64)
Cerebellar cortex23 (19–30)17 (14–21)0.087.1(5.7–8.7)6.0(4.9–7.4)0.50 (0.48–0.53)0.53 (0.50–0.55)
Brain stem15 (13–18)11 (9–13)0.024.8(3.9–5.9)3.9(3.2–4.8)0.51 (0.48–0.53)0.54 (0.51–0.57)
White matter10 (9–12)8 (7–9)0.043.7(3.0–4.6)3.3(2.6–4.0)0.54 (0.51–0.57)0.56 (0.53–0.59)
P for all regions0.250.08
  • Data are medians(95% CI). P for overall GLP-1 effect on K1glc = 0.015. For calculation of Kglc and LC, see research design and methods.