TABLE 2

Anthropometric and metabolic characteristics of 5,722 treatment-naive Danish individuals from the population-based Inter99 study sample, stratified according to FTO rs9939609 genotype

TTTAAAPAddPDomPRec
n (men/women)1,977 (969/1,008)2,783 (1,423/1,360)962 (461/501)
Age (years)46.2 ± 845.9 ± 846.5 ± 8
Obesity-related measures
    BMI (kg/m2)25.9 ± 7.926.2 ± 4.627.0 ± 4.91 × 10−9*2 × 10−5*4 × 10−9*
    Height (m)1.72 ± 0.91.73 ± 0.91.72 ± 0.90.60.70.6
    Body weight (kg)76.9 ± 15.278.2 ± 16.080.3 ± 17.22 × 10−9*3 × 10−5*4 × 10−9*
    Waist circumference (cm)85.6 ± 12.886.6 ± 13.387.9 ± 13.71 × 10−7*8 × 10−5*2 × 10−6*
    Waist-to-hip ratio0.85 ± 0.090.86 ± 0.090.86 ± 0.090.030.030.2
Fasting serum lipids (mmol/l)
    Triglyceride1.0 (0.8–1.5)1.1 (0.8–1.5)1.1 (0.8–1.6)0.90.70.4
    Total cholesterol5.6 ± 1.15.5 ± 1.15.6 ± 1.00.20.10.6
    HDL cholesterol1.4 ± 0.41.4 ± 0.41.4 ± 0.40.80.50.2
Plasma glucose (mmol/l)
    Fasting5.5 ± 0.85.5 ± 0.85.6 ± 0.80.10.030.5
    30 min8.7 ± 1.98.7 ± 1.98.7 ± 1.90.20.30.4
    120 min6.2 ± 2.06.2 ± 2.26.4 ± 2.10.90.60.4
Serum insulin (pmol/l)
    Fasting33 (23–49)35 (24–52)35 (24–52)0.30.90.1
    30 min239 (172–340)247 (177–358)253 (179–368)0.80.90.5
    120 min157 (101–254)152 (91–249)166 (101–277)0.10.030.9
Derived indices
    BIGTT-Si9.3 (6.5–12.2)9.2 (6.4–12.1)8.8 (5.6–11.7)0.004*0.060.003*
    BIGTT-AIR1,585 (12.61–20.16)1,639 (12.88–21.12)1,663 (13.20–21.46)0.001*0.005*0.02
    HOMA-IR8.1 (5.5–12.7)8.4 (5.7–12.9)8.6 (5.8–13.4)0.20.80.1
  • Data are means ± SD or median (interquartile range). Values of serum insulin, values derived from insulin variables, and values of serum triglyceride were logarithmically transformed before statistical analysis. All analyses were made using additive (Add), dominant (Dom), and recessive (Rec) models. Plasma glucose and serum insulin were measured in the fasting state and after an OGTT. Calculated P values were adjusted for age and sex for obesity-related measures; sex, age, and BMI for serum lipids, serum insulin, plasma glucose, and homeostasis model assessment of insulin resistance (HOMA-IR); and age for the BIGTT-Si and BIGTT-AIR indices. Homeostasis model assessment of insulin resistance was calculated as fasting plasma glucose (mmol/l) × fasting serum insulin (pmol/l)/22.5. BIGTT-Si and BIGTT-AIR were calculated as previously described (ref. 15).

  • *

    * P value remained significant after Benjamini and Hochberg correction.