TABLE 2

Associations of HHEX SNPs rs1111875 and rs7923837 with metabolic parameters

GenotypeHHEX rs1111875 (MAF 0.39)
P1P2P3HHEX rs7923837 (MAF 0.34)
P1P2P3
CCCTTTGGGAAA
n30341812335639591
Fasting glucose (mmol/l)5.10 ± 0.555.09 ± 0.545.01 ± 0.440.30.115.11 ± 0.565.08 ± 0.525.01 ± 0.430.40.3
Glucose 120 min OGTT (mmol/l)6.28 ± 1.586.25 ± 1.536.20 ± 1.421.00.86.27 ± 1.566.27 ± 1.546.15 ± 1.400.90.8
AUC glucose OGTT (mmol · l−1 · min−1)872 ± 175862 ± 181863 ± 1510.70.9870 ± 177863 ± 178862 ± 1520.90.9
Fasting insulin (pmol/l)48.3 ± 32.554.2 ± 73.844.4 ± 29.90.220.0648.1 ± 31.754.4 ± 75.944.8 ± 27.50.50.20
Insulin 30 min OGTT (pmol/l)360 ± 225403 ± 282385 ± 2340.110.15362 ± 220407 ± 288382 ± 2400.130.4
AUC insulin OGTT (pmol · l−1 · min−1)247,575 ± 154,834263,378 ± 188,720246,755 ± 135,3070.40.7244,007 ± 147,702268,633 ± 194,318242,962 ± 133,3610.40.7
AUC insulin 0–10 min IVGTT (pmol · l−1 · min−1)*3,580 ± 2,8424,013 ± 3,2323,616 ± 2,3590.170.190.233,433 ± 2,4344,173 ± 3,5143,647 ± 2,2090.0130.0460.014
AUC insulin 0–10 min IVGTT over basal insulin (pmol · l−1 · min−1)*3,062 ± 2,5023,471 ± 2,7493,198 ± 2,2060.150.200.212,956 ± 2,2823,602 ± 2,9193,220 ± 2,0610.0160.0490.025
AUC insulin 10–60 min IVGTT (pmol · l−1 · min−1)*11,164 ± 11,34011,450 ± 10,6999,576 ± 7,0980.30.41.010,559 ± 9,98711,877 ± 11,6499,652 ± 6,0860.190.70.4
AUC insulin 10–60 min IVGTT over basal insulin (pmol · l−1 · min−1)*8,601 ± 9,3168,737 ± 8,1777,449 ± 6,2220.30.50.88,205 ± 8,8109,006 ± 8,5267,491 ± 5,1960.140.50.22
HOMA-IR (mmol−1 · l−1 · μU−1 · ml−1)11.1 ± 8.212.8 ± 20.610.0 ± 7.00.170.04211.1 ± 7.912.9 ± 21.110.1 ± 6.50.40.17
M (μmol · kg−1 · min−1)42.7 ± 16.541.1 ± 16.641.0 ± 16.40.50.642.8 ± 17.241.2 ± 16.540.0 ± 14.20.40.5
  • n = 844. P values given for unadjusted data (P1). Additional P values are presented for all data after adjustment for center, family relationship, sex, age, and BMI (P2) and for IVGTT data after additional adjustment for HOMA-IR (P3). AUC, area under the curve; MAF, minor allele frequency. M = clamp-derived insulin sensitivity.

  • *

    * subgroup, n = 758;

  • subgroup, n = 575.