TABLE 1

Tests for association of rs7566605 in the vicinity of INSIG2 with SDS BMI and cardiovascular risk factor profile at baseline in 293 obese children

Homozygous GGHeterozygous CGHomozygous CCP
n14712521
SDS BMI2.46 (2.14–2.75)2.36 (2.07–2.71)2.40 (2.11–2.73)0.124
SBP (mmHg)120 (111–131)112 (111–125)115 (111–126)0.146*
DBP (mmHg)61 (57–71)61 (55–75)61 (55–71)0.578*
Total cholesterol (mg/dl)170 (152–192)167 (153–190)167 (152–190)0.291
LDL cholesterol (mg/dl)104 (84–124)104 (89–125)102 (85–124)0.267*
HDL cholesterol (mg/dl)49 (43–58)48 (51–54)48 (42–56)0.188
Triglycerides (mg/dl)98 (72–135)106 (77–136)102 (76–138)0.642*
Insulin (mIU/l)16 (11–23)15 (11–21)16 (11–22)0.636*
HOMA3.3 (2.3–4.82)3.2 (2.3–4.6)3.3 (2.3–4.8)0.785*
  • Data are median (interquartile range). DBP, diastolic blood pressure; SBP, systolic blood pressure. P values derived from linear regression analyses under allele-dose model adjusted for sex, age, stage of puberty, and baseline SDS BMI.

  • * Non-normally distributed variables were log transformed.