TABLE 2

Expression of selective immune-related genes with an >1.5-fold difference in the developing human fetal pancreas

Gene title and categoryEarly second trimesterLate second trimester
MHC class II molecules
    HLA-DQB11.531.57
    HLA-DRB12.151.6
    HLA-DRB41.741.47
    HLA-DRB51.791.49
Chemokines and adhesion molecules
    Chemokine ligand 19 (CCL19)2.071.54
    N-Cadherin (CDH2)−2.5−2.9
    Neuronal cell adhesion molecule (NRCAM)1.651.87
    Trophinin (TRO)−2.7−3.7
Innate molecules
    Immune costimulatory protein B7-H43.043.81
    Immunoglobulin κ constant (IGKC)1.722.03
    Immunoglobulin superfamily member 1 (IGSF1)1.761.89
    Immunoglobulin superfamily member 3 (IGSF3)−1.67−2.17
Complement component
    Complement component 3 (C3)2.071.60
    Mannose receptor C type (MRC1)−1.64−2.44
ILs
    IL 22 receptor α1 (IL22RA1)1.963.18
    IL enhancer binding factor 2 (ILF2)−1.96−2.44
Apoptotic markers
    TNFSF101.911.74
  • Data are fold change and are normalized to first trimester.