TABLE 1

Raw scores for each cognitive test at baseline and during each plateau period with either detemir or regular human insulin in euglycemic and hypoglycemic studies

	Time of test (min)						P value
	0	60	120	180	240	300	P value
Nominal plasma glucose (mg/dl) (Eu/Hypo)	Basal	90/90	90/78	90/66	90/54	90/42
Verbal M*
Eu-Det	4.8 ± 0.4	4.6 ± 1.0	4.5 ± 0.7	4.0 ± 1.4	4.2 ± 0.9	4.0 ± 1.2	0.0021
Eu-HI	4.9 ± 0.3	4.9 ± 0.3	4.0 ± 1.7	4.0 ± 1.5	4.3 ± 0.8	4.1 ± 1.3
Hypo-Det	4.9 ± 0.3	4.2 ± 1.3	4.5 ± 0.7	4.4 ± 1.1	3.7 ± 1.6	2.9 ± 2.0†
Hypo-HI	4.8 ± 0.6	4.8 ± 0.4	4.5 ± 0.5	3.9 ± 1.3	4.3 ± 0.9	2.6 ± 2.0†
Trail A‡
Eu-Det	64.2 ± 28.9	37.3 ± 20.0	57.3 ± 16.4	62.9 ± 21.6	60.6 ± 20.7	69.4 ± 18.3	0.076
Eu-HI	64.7 ± 19.2	38.8 ± 26.2	61.8 ± 14.2	64.6 ± 11.1	65.4 ± 14.6	66.6 ± 10.9
Hypo-Det	63.2 ± 11.3	27.4 ± 7.2	54.9 ± 10.1	76.6 ± 14.1	63.8 ± 14.1	74.0 ± 14.2
Hypo-HI	61.6 ± 14.1	33.1 ± 13.7	61.5 ± 11.9	73.1 ± 20.4	58.4 ± 16.1	67.9 ± 18.2
Trail B‡
Eu-Det	53.6 ± 16.9	50.0 ± 21.3	48.0 ± 17.2	53.8 ± 16.6	51.1 ± 14.9	49.5 ± 15.8	0.1100
Eu-HI	53.3 ± 14.6	48.3 ± 16.6	52.8 ± 17.6	53.9 ± 17.0	49.9 ± 14.1	48.9 ± 13.4
Hypo-Det	42.3 ± 12.9	41.9 ± 14.3	47.2 ± 12.9	49.8 ± 16.2	52.1 ± 17.4	54.4 ± 19.0
Hypo-HI	50.2 ± 17.0	46.0 ± 18.6	45.8 ± 14.5	49.4 ± 15.7	50.5 ± 19.0	50.6 ± 19.2
Verbal F*
Eu-Det	12.4 ± 4.0	12.9 ± 4.4	12.6 ± 3.5	12.5 ± 3.5	14.1 ± 3.7	14.6 ± 4.0	0.0126
Eu-HI	12.8 ± 3.5	11.8 ± 5.0	11.7 ± 4.8	10.3 ± 2.3	13.0 ± 4.4	14.8 ± 4.6
Hypo-Det	13.5 ± 3.4	13.2 ± 3.9	13.1 ± 4.3	11.9 ± 3.5	11.4 ± 1.8	11.6 ± 3.6†
Hypo-HI	13.3 ± 2.5	13.3 ± 4.3	13.3 ± 4.4	11.8 ± 2.6	13.0 ± 4.1
Digit SB*
Eu-Det	5.2 ± 1.1	4.7 ± 1.7	5.3 ± 1.6	5.3 ± 1.7	5.5 ± 1.4	4.9 ± 1.6	0.0600
Eu-HI	4.9 ± 1.5	5.1 ± 1.7	5.1 ± 1.4	5.1 ± 1.5	5.0 ± 1.8	5.3 ± 1.6
Hypo-Det	5.8 ± 1.4	5.9 ± 1.6	6.0 ± 1.2	6.1 ± 1.3	5.8 ± 1.3	4.8 ± 1.9
Hypo-HI	5.4 ± 1.6	5.6 ± 1.7	5.6 ± 1.3	5.9 ± 1.4	5.7 ± 1.6	5.4 ± 1.6
PASAT*
Eu-Det	51.8 ± 8.8	56.1 ± 4.5	56.5 ± 4.3	56.9 ± 3.6	57.0 ± 4.4	58.1 ± 2.9	0.0002
Eu-HI	56.7 ± 6.1	57.0 ± 4.9	56.7 ± 3.1	58.0 ± 3.6	56.2 ± 4.3	57.0 ± 3.8
Hypo-Det	58.4 ± 2.3	58.8 ± 1.6	58.3 ± 2.2	56.9 ± 3.5	57.6 ± 2.4	51.0 ± 8.7†§
Hypo-HI	58.2 ± 2.9	58.0 ± 2.1	56.7 ± 3.0	59.0 ± 2.1	56.5 ± 3.2	55.1 ± 5.2
Stroop word*
Eu-Det	111.7 ± 18.7	118.9 ± 13.9	119.4 ± 12.8	117.7 ± 16.1	118.6 ± 13.8	116.1 ± 11.0	0.0000
Eu-HI	118.0 ± 18.8	116.1 ± 12.8	118.1 ± 15.2	116.8 ± 20.1	117.0 ± 15.1	120.7 ± 16.4
Hypo-Det	120.2 ± 16.9	118.0 ± 18.1	118.8 ± 19.2	115.9 ± 18.4	107.8 ± 15.4	95.3 ± 17.8†§
Hypo-HI	118.9 ± 13.6	118.5 ± 15.7	112.4 ± 12.5	116.6 ± 15.8	109.2 ± 11.8	102.8 ± 15.0†
Stroop color*
Eu-Det	82.4 ± 9.5	83.2 ± 7.6	82.5 ± 7.3	83.4 ± 9.3	85.8 ± 7.8	83.9 ± 9.0	0.0000
Eu-HI	79.3 ± 9.3	82.1 ± 11.8	83.3 ± 8.2	83.1 ± 11.3	83.9 ± 11.6	85.3 ± 9.9
Hypo-Det	84.7 ± 15.4	85.9 ± 18.5	83.5 ± 18.1	81.3 ± 18.2	76.1 ± 10.0†	69.2 ± 11.2†
Hypo-HI	82.6 ± 9.4	83.5 ± 11.2	84.0 ± 10.0	80.6 ± 9.5	77.1 ± 15.6†	68.7 ± 15.5†
Stroop color-word*
Eu-Det	52.9 ± 10.0	55.3 ± 10.3	56.6 ± 12.1	55.4 ± 9.0	56.2 ± 10.4	55.9 ± 10.3	0.0000
Eu-HI	53.4 ± 8.8	55.4 ± 9.2	55.5 ± 10.3	59.3 ± 10.2	52.8 ± 8.6	56.9 ± 11.3
Hypo-Det	63.2 ± 11.4	64.5 ± 14.1	61.6 ± 10.4	60.8 ± 10.2	59.6 ± 11.2	51.5 ± 11.3†
Hypo-HI	62.1 ± 13.8	58.5 ± 9.9	62.6 ± 11.6	59.7 ± 8.7	58.2 ± 11.9	51.3 ± 10.9†

Data are means ± SD. Det, detemir; HI, regular human insulin; Eu-, euglycemic studies; Hypo-, hypoglycemic studies.
* Number of responses;
‡ time in seconds;
† Hypo≠Eu;
§ Hypo-Det≠Hypo-HI, P < 0.05.