TABLE 1

Raw scores for each cognitive test at baseline and during each plateau period with either detemir or regular human insulin in euglycemic and hypoglycemic studies

Time of test (min)P value
060120180240300
Nominal plasma glucose (mg/dl) (Eu/Hypo)Basal90/9090/7890/6690/5490/42
Verbal M*
    Eu-Det4.8 ± 0.44.6 ± 1.04.5 ± 0.74.0 ± 1.44.2 ± 0.94.0 ± 1.20.0021
    Eu-HI4.9 ± 0.34.9 ± 0.34.0 ± 1.74.0 ± 1.54.3 ± 0.84.1 ± 1.3
    Hypo-Det4.9 ± 0.34.2 ± 1.34.5 ± 0.74.4 ± 1.13.7 ± 1.62.9 ± 2.0
    Hypo-HI4.8 ± 0.64.8 ± 0.44.5 ± 0.53.9 ± 1.34.3 ± 0.92.6 ± 2.0
Trail A
    Eu-Det64.2 ± 28.937.3 ± 20.057.3 ± 16.462.9 ± 21.660.6 ± 20.769.4 ± 18.30.076
    Eu-HI64.7 ± 19.238.8 ± 26.261.8 ± 14.264.6 ± 11.165.4 ± 14.666.6 ± 10.9
    Hypo-Det63.2 ± 11.327.4 ± 7.254.9 ± 10.176.6 ± 14.163.8 ± 14.174.0 ± 14.2
    Hypo-HI61.6 ± 14.133.1 ± 13.761.5 ± 11.973.1 ± 20.458.4 ± 16.167.9 ± 18.2
Trail B
    Eu-Det53.6 ± 16.950.0 ± 21.348.0 ± 17.253.8 ± 16.651.1 ± 14.949.5 ± 15.80.1100
    Eu-HI53.3 ± 14.648.3 ± 16.652.8 ± 17.653.9 ± 17.049.9 ± 14.148.9 ± 13.4
    Hypo-Det42.3 ± 12.941.9 ± 14.347.2 ± 12.949.8 ± 16.252.1 ± 17.454.4 ± 19.0
    Hypo-HI50.2 ± 17.046.0 ± 18.645.8 ± 14.549.4 ± 15.750.5 ± 19.050.6 ± 19.2
Verbal F*
    Eu-Det12.4 ± 4.012.9 ± 4.412.6 ± 3.512.5 ± 3.514.1 ± 3.714.6 ± 4.00.0126
    Eu-HI12.8 ± 3.511.8 ± 5.011.7 ± 4.810.3 ± 2.313.0 ± 4.414.8 ± 4.6
    Hypo-Det13.5 ± 3.413.2 ± 3.913.1 ± 4.311.9 ± 3.511.4 ± 1.811.6 ± 3.6
    Hypo-HI13.3 ± 2.513.3 ± 4.313.3 ± 4.411.8 ± 2.613.0 ± 4.1
Digit SB*
    Eu-Det5.2 ± 1.14.7 ± 1.75.3 ± 1.65.3 ± 1.75.5 ± 1.44.9 ± 1.60.0600
    Eu-HI4.9 ± 1.55.1 ± 1.75.1 ± 1.45.1 ± 1.55.0 ± 1.85.3 ± 1.6
    Hypo-Det5.8 ± 1.45.9 ± 1.66.0 ± 1.26.1 ± 1.35.8 ± 1.34.8 ± 1.9
    Hypo-HI5.4 ± 1.65.6 ± 1.75.6 ± 1.35.9 ± 1.45.7 ± 1.65.4 ± 1.6
PASAT*
    Eu-Det51.8 ± 8.856.1 ± 4.556.5 ± 4.356.9 ± 3.657.0 ± 4.458.1 ± 2.90.0002
    Eu-HI56.7 ± 6.157.0 ± 4.956.7 ± 3.158.0 ± 3.656.2 ± 4.357.0 ± 3.8
    Hypo-Det58.4 ± 2.358.8 ± 1.658.3 ± 2.256.9 ± 3.557.6 ± 2.451.0 ± 8.7§
    Hypo-HI58.2 ± 2.958.0 ± 2.156.7 ± 3.059.0 ± 2.156.5 ± 3.255.1 ± 5.2
Stroop word*
    Eu-Det111.7 ± 18.7118.9 ± 13.9119.4 ± 12.8117.7 ± 16.1118.6 ± 13.8116.1 ± 11.00.0000
    Eu-HI118.0 ± 18.8116.1 ± 12.8118.1 ± 15.2116.8 ± 20.1117.0 ± 15.1120.7 ± 16.4
    Hypo-Det120.2 ± 16.9118.0 ± 18.1118.8 ± 19.2115.9 ± 18.4107.8 ± 15.495.3 ± 17.8§
    Hypo-HI118.9 ± 13.6118.5 ± 15.7112.4 ± 12.5116.6 ± 15.8109.2 ± 11.8102.8 ± 15.0
Stroop color*
    Eu-Det82.4 ± 9.583.2 ± 7.682.5 ± 7.383.4 ± 9.385.8 ± 7.883.9 ± 9.00.0000
    Eu-HI79.3 ± 9.382.1 ± 11.883.3 ± 8.283.1 ± 11.383.9 ± 11.685.3 ± 9.9
    Hypo-Det84.7 ± 15.485.9 ± 18.583.5 ± 18.181.3 ± 18.276.1 ± 10.069.2 ± 11.2
    Hypo-HI82.6 ± 9.483.5 ± 11.284.0 ± 10.080.6 ± 9.577.1 ± 15.668.7 ± 15.5
Stroop color-word*
    Eu-Det52.9 ± 10.055.3 ± 10.356.6 ± 12.155.4 ± 9.056.2 ± 10.455.9 ± 10.30.0000
    Eu-HI53.4 ± 8.855.4 ± 9.255.5 ± 10.359.3 ± 10.252.8 ± 8.656.9 ± 11.3
    Hypo-Det63.2 ± 11.464.5 ± 14.161.6 ± 10.460.8 ± 10.259.6 ± 11.251.5 ± 11.3
    Hypo-HI62.1 ± 13.858.5 ± 9.962.6 ± 11.659.7 ± 8.758.2 ± 11.951.3 ± 10.9
  • Data are means ± SD. Det, detemir; HI, regular human insulin; Eu-, euglycemic studies; Hypo-, hypoglycemic studies.

  • * Number of responses;

  • time in seconds;

  • Hypo≠Eu;

  • § Hypo-Det≠Hypo-HI, P < 0.05.