TABLE 1

General assessment parameters in each of the study groups

Body weight (g)Glucose (mmol/l)Glycated Hb (%)Systolic blood pressure (mmHg)Albumin excretion (μg/day)Renal mass (g/m2)Creatinine clearance (ml/min)ERPF (ml/min)
c57 (wild type)33 ± 111.1 ± 1.64.1 ± 0.1121 ± 147 ×/÷ 1.133 ± 10.26 ± 0.020.7 ± 0.1
c57 + ACEi32 ± 110.5 ± 1.24.1 ± 0.1113 ± 1*30 ×/÷ 1.1*34 ± 10.27 ± 0.040.5 ± 0.1
c57 + ACE2i33 ± 18.0 ± 1.0*3.8 ± 0.2120 ± 230 ×/÷ 1.1*35 ± 10.34 ± 0.021.4 ± 0.2
c57 + ACEi + ACE2i33 ± 18.4 ± 1.3*3.6 ± 0.1*118 ± 139 ×/÷ 1.136 ± 10.32 ± 0.031.3 ± 0.1
Diabetes + c5726 ± 1*30 ± 1.3*12.0 ± 0.6*119 ± 2218 ×/÷ 1.1*46 ± 1*0.66 ± 0.01*2.1 ± 0.2*
Diabetes + c57 + ACEi27 ± 2*27 ± 1.4*13.5 ± 0.6113 ± 1*102 ×/÷ 1.1*45 ± 1*0.66 ± 0.02*1.5 ± 0.1*
Diabetes + c57 + ACE2i28 ± 2*29 ± 1.2*13.7 ± 0.7*125 ± 2302 ×/÷ 1.1*42 ± 1*0.37 ± 0.03*1.1 ± 0.1*
Diabetes + c57 + ACEi + ACE2i26 ± 2 *28 ± 1.3*12.9 ± 0.6*125 ± 1*294 ×/÷ 1.3*40 ± 1*0.28 ± 0.031.2 ± 0.1*
ACE2 KO31 ± 1*9.1 ± 1.1*3.5 ± 0.2*122 ± 235 ×/÷ 1.1*34 ± 10.33 ± 0.021.3 ± 0.2*
ACE2 KO + ACEi30 ± 1*9.0 ± 1.3*4.0 ± 0.1120 ± 339 ×/÷ 1.132 ± 10.27 ± 0.041.1 ± 0.1*
Diabetes + ACE2 KO24 ± 1*29.1 ± 1*11.9 ± 0.6*126 ± 2*193 ×/÷ 1.1*43 ± 1*0.45 ± 0.03*1.2 ± 0.1*
Diabetes + ACE2 KO +ACEi25 ± 1*28.5 ± 1*13.9 ± 0.4*135 ± 4*255 ×/÷ 1.1*36 ± 1§0.32 ± 0.03§0.8 ± 0.1§
  • Data are means ± SEM except for AER, which is shown as its geometric mean ×/÷ 1.1 tolerance factor. P < 0.05

  • * vs. control c57,

  • vs. diabetic c57,

  • vs. control ACE2 KO, and

  • § vs. diabetic ACE2 KO. ERPF, effective renal plasma flow.