TABLE 3

Trait association with interaction between PPARG2 and HNF4A among BetaGene subjects

PPARG2 Pro12Ala genotypeInteraction P value
Ala/Pro or Ala/AlaPro/Pro
HNF4A rs2144908 genotype
A/AA/GG/GA/AA/GG/G
Additive*Recessive*
n30442310219084
BMI (kg/m2)26.3 (0.7)27.4 (0.8)27.8 (0.9)27.8 (1.0)27.8 (1.0)27.9 (1.1)11
Fasting glucose (mmol/l)5.1 (0.2)5.1 (0.3)5.0 (0.2)5.1 (0.2)5.1 (0.2)5.1 (0.2)11
2-h glucose (mmol/l)6.3 (0.6)7.0 (0.9)7.0 (0.8)7.0 (0.8)7.1 (0.8)7.0 (0.8)11
Fasting insulin (pmol/l)36 (15)57 (46)79 (77)53 (28)59 (42)54 (32)0.6360.294
2-h insulin (pmol/l)279 (93)467 (212)625 (292)405 (142)413 (179)383 (155)0.0540.039
30′ Δinsulin (pmol/l)334 (59)432 (98)588 (173)406 (93)412 (111)396 (118)0.2220.021
SG (×10−2 min−1)1.79 (0.18)1.56 (0.22)1.47 (0.21)1.69 (0.19)1.62 (0.21)1.59 (0.20)11
SI (×10−3 min−1 per pmol/l)3.92 (0.88)2.73 (0.92)1.95 (0.72)2.74 (0.73)2.71 (0.85)2.89 (0.85)0.00110.0006
AIR (pmol/l × 10 min)4,480 (921)5,198 (1,353)6,832 (2,707)5,230 (1,410)5,060 (1,538)4,567 (1,534)0.9691
Disposition index16,113 (2,686)13,026 (3,152)12,426 (2,829)13,561 (2,882)12,742 (2,805)12,257 (2,899)11
  • Genotype-specific trait values are shown as mean (SD) adjusted for age, sex, and BMI (except in the case of BMI). The interaction P value is Bonferroni-corrected for 30 tests, as described in research design and methods.

  • * Genetic model assumed for HNF4A rs2144908 in the interaction with PPARG2. PPARG2 Pro12Ala was assumed to follow a dominant genetic model for Ala.