TABLE 4

SI association with interaction between PPARG2 and HNF4A among IRASFS subjects

PPARG2 Pro12Ala genotypeInteraction P value
Ala/Pro or Ala/AlaPro/Pro
HNF4A rs2144908 genotype
A/AA/GG/GA/AA/GG/GAdditive*Recessive*
San Antonio
    n32632375187104
3.65 (1.94)3.15 (1.57)2.45 (1.33)2.71 (1.43)2.58 (1.21)2.42 (1.45)0.0560.018
San Luis Valley
    n19442585214109
3.18 (1.69)3.74 (1.74)3.99 (2.04)3.22 (1.58)3.30 (1.69)3.26 (1.73)0.4010.176
  • Genotype-specific trait values are shown as mean (SD) adjusted for age, sex, and BMI.

  • * Genetic model assumed for HNF4A rs2144908 in the interaction with PPARG2. PPARG2 Pro12Ala was assumed to follow a dominant genetic model for Ala.