TABLE 1

Characteristics of DIABHYCAR cohorts at baseline according to CAD incidence status

Incident CADP value
YesNo
Patients (n)4642,658
Men (%)8071<0.0001
Age (years)67 ± 865 ± 8<0.0001
Age at diagnosis of diabetes (years)56 ± 1055 ± 100.11
Known duration of diabetes (years)11 ± 810 ± 80.005
Fasting plasma glucose (mmol/l)9.6 ± 2.99.5 ± 3.10.53
A1C (%)8.0 ± 1.87.8 ± 1.80.02
BMI (kg/m2)28.9 ± 4.429.5 ± 4.70.01
Ponderal status: lean/overweight/obese (%)*13/49/3812/43/450.03
Triglycerides (mmol/l)2.38 ± 1.322.19 ± 1.44<0.0003
Total cholesterol (mmol/l)5.97 ± 1.105.76 ± 1.060.0002
LDL cholesterol (mmol/l)3.68 ± 0.903.50 ± 0.880.0006
HDL cholesterol (mmol/l)1.25 ± 0.311.33 ± 0.36<0.0001
Creatinine clearance (ml/min)80 ± 2787 ± 30<0.0001
Urinary albumin excretion (mg/l)391 ± 1207202 ± 446<0.0001
UAE: microalbuminuria/macroalbuminuria (%)68/3278/22<0.0001
Arterial hypertension (%)§62550.01
Tobacco smoking (%)15140.67
Randomization group: ramipril (%)47500.37
Previous myocardial infarction (%)134<0.0001
Angina pectoris (%)2310<0.0001
  • Data are means ± SD. CAD represents the incident cases of myocardial infarction, CABG, or sudden death during the study. Statistics of quantitative parameters are Students t test performed with log-transformed data.

  • * Ponderal status: lean, BMI <25 kg/m2; overweight, 25 kg/m2 ≤ BMI < 30 kg/m2; obese, BMI ≥30 kg/m2.

  • Data available for 353 subjects with CAD and 2,145 subjects without CAD.

  • UAE: microalbuminuria, 20 mg/l ≤ UAE < 200 mg/l; macroalbuminuria, UAE ≥200 mg/l.

  • § Arterial hypertension: systolic blood pressure >140 mmHg and/or diastolic blood pressure >90 mmHg; or systolic blood pressure and diastolic blood pressure below these values in the presence of antihypertensive medication and history of hypertension.

  • Randomization group in the original DIABHYCAR study ramipril versus placebo.