TABLE 3

Genotype frequency and prevalence of CAD at baseline in the DIABHYCAR cohort

SubjectsCAD−866G>A:N (genotype frequency)A allele in a dominant model
GGGAAAUnadjusted modelAdjusted model*
OR (95% CI)P valueOR (95% CI)P value
AllYes216 (0.451)197 (0.411)66 (0.138)
No1059 (0.401)1230 (0.465)354 (0.134)0.81 (0.67–0.98)0.040.81 (0.66–0.99)0.04
MenYes179 (0.469)149 (0.390)54 (0.141)
No744 (0.392)908 (0.478)247 (0.130)0.73 (0.59–0.91)0.0050.74 (0.59–0.92)0.008
WomenYes37 (0.381)48 (0.495)12 (0.124)
No315 (0.423)322 (0.433)107 (0.144)1.19 (0.77–1.85)0.431.13 (0.71–1.80)0.61
  • CAD: history of myocardial infarction or angina pectoris at baseline. OR for the A allele in a dominant model (XA vs. GG) determined in logistic regression analyses. Computations performed without adjustment for covariables or

  • * adjusted for age, BMI, total cholesterol, HDL cholesterol, triglycerides, urinary albumin excretion, creatinine clearance, A1C, duration of diabetes, and arterial hypertension.