TABLE 2

Frequency distribution of DRB1-DQB1 haplotypes in Caucasian probands and in AFBAC

DRB1DQA1DQB1AFBACProbandTransOR (95% CI)χ2P valueEffect on T1D*
0101010105019.06.644.60.71 (0.52–0.98)3.960.047
0101010205040.20.150.00.37 (0.03–4.08)0.700.40
0102010105011.00.732.50.66 (0.25–1.71)0.740.39
0103010105010.60.125.00.15 (0.02–1.26)3.990.046
03010501020112.534.170.93.64 (2.89–4.58)95.332 × 10−22S3
0401030102010.10.257.11.48 (0.13–16.37)0.100.75
0401030103013.91.433.60.35 (0.20–0.63)12.784 × 10−4
0401030103024.528.184.58.39 (5.97–11.80)156.736 × 10−36S2
0402030103021.03.573.33.63 (1.76–7.49)13.283 × 10−4S4
0403030103021.20.313.30.27 (0.08–0.84)5.690.017
0404030103023.25.057.11.59 (1.01–2.49)3.880.049S5
0404030104020.10.250.01.48 (0.13–16.37)0.100.75
0405030102010.30.542.11.48 (0.37–5.95)0.310.58
0405030103020.22.587.311.37 (2.71–47.68)16.884 × 10−5S1
0407030103011.40.28.00.11 (0.03–0.50)11.686 × 10−4
0408030103010.40.120.00.18 (0.02–1.65)2.810.094
0408030103040.30.756.51.98 (0.52–7.49)1.030.31
07010201020110.13.528.20.32 (0.22–0.46)35.672 × 10−9
0701020103034.30.13.60.02 (0.00–0.13)48.334 × 10−12P1
0801030103020.00.271.42.170.14
0801040104022.43.150.01.25 (0.73–2.14)0.680.41
0803060103010.30.00.00.003.960.047
0804040104020.20.250.00.74 (0.10–5.26)0.090.76
0901030102010.00.2100.01.450.23
0901030103031.60.845.20.53 (0.23–1.19)2.400.12
1001010105010.70.326.10.49 (0.14–1.75)1.220.27
1101050103016.51.217.90.18 (0.10–0.32)39.803 × 10−10
1102050103010.40.223.10.37 (0.07–2.02)1.400.24
1103050103011.00.225.00.25 (0.07–0.91)5.060.024
1104010306030.30.112.50.25 (0.03–2.37)1.690.19
1104050103012.30.26.30.07 (0.02–0.30)21.883 × 10−6P4
1201050103011.10.330.30.29 (0.09–0.94)4.680.031
1301010306035.90.814.80.13 (0.07–0.26)43.594 × 10−11
1302010206042.62.246.10.87 (0.49–1.52)0.260.61
1302010206090.30.022.20.003.960.047
1303050103011.00.110.00.08 (0.01–0.64)9.010.003P5
1401010105032.10.00.00.02 (0.00–0.32)23.511 × 10−6P2
1404010105030.10.150.00.74 (0.05–11.85)0.050.83
1501010205010.20.00.00.002.640.10
15010102060212.00.43.90.03 (0.01–0.07)127.142 × 10−29P3
1501010206030.30.00.00.003.960.047
1502010306010.70.213.30.25 (0.05–1.22)3.370.066
1601010205022.01.035.70.49 (0.23–1.02)3.670.055
1602010205020.10.150.00.74 (0.05–11.85)0.050.83
Total8981,214721.725 × 10−124
  • Data are %.

  • * For haplotypes with a frequency >1% in either probands or control subjects, the five most susceptible (S) and the five most protective (P) haplotypes are indicated. T1D, type 1 diabetes.