Relative predispositional effects of seven DR-DQ haplotypes
| Haplotype | AFBAC | Type 1 diabetes | Association in all samples | Association excluding DR3, DR4, and protective haplotypes* | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | Rank | OR (95% CI) | P value | Rank | |||
| DRB1*0801 DQA1*0401 DQB1*0402 | 2.45 | 3.05 | 1.25 (0.73–2.14) | 0.41 | 1 | 2.58 (1.48–4.48) | 0.0013 | 1 |
| DRB1*1302 DQA1*0102 DQB1*0604 | 2.56 | 2.23 | 0.87 (0.49–1.52) | 0.61 | 2 | 1.72 (0.96–3.07) | 0.076 | 2 |
| DRB1*0101 DQA1*0101 DQB1*0501 | 9.02 | 6.60 | 0.71 (0.52–0.98) | 0.047 | 3 | 1.55 (1.08–2.22) | 0.029 | 3 |
| DRB1*0901 DQA1*0301 DQB1*0303 | 1.56 | 0.82 | 0.53 (0.23–1.19) | 0.12 | 4 | 1.00 (0.44–2.28) | 0.73 | 4 |
| DRB1*1601 DQA1*0102 DQB1*0502 | 2.00 | 0.99 | 0.49 (0.23–1.02) | 0.055 | 5 | 0.93 (0.44–1.96) | 0.66 | 5 |
| DRB1*0401 DQA1*0301 DQB1*0301 | 3.90 | 1.40 | 0.35 (0.20–0.63) | 4 × 10−4 | 6 | 0.65 (0.36–1.20) | 0.17 | 6 |
| DRB1*0701 DQA1*0201 DQB1*0201 | 10.10 | 3.50 | 0.32 (0.22–0.46) | 2 × 10−9 | 7 | 0.58 (0.38–0.87) | 0.015 | 7 |
Data are %.
* The protective haplotypes excluded are DRB1*150x DQB1*060x; all DRB1*11, -*12, -*13, and -*14 haplotypes with DQB1*0301; DRB1*140x DQB1*050x; and DRB1*0701 DQB1*0303 haplotypes.