TABLE 4

Relative predispositional effects of seven DR-DQ haplotypes

HaplotypeAFBACType 1 diabetesAssociation in all samplesAssociation excluding DR3, DR4, and protective haplotypes*
OR (95% CI)P valueRankOR (95% CI)P valueRank
DRB1*0801 DQA1*0401 DQB1*04022.453.051.25 (0.73–2.14)0.4112.58 (1.48–4.48)0.00131
DRB1*1302 DQA1*0102 DQB1*06042.562.230.87 (0.49–1.52)0.6121.72 (0.96–3.07)0.0762
DRB1*0101 DQA1*0101 DQB1*05019.026.600.71 (0.52–0.98)0.04731.55 (1.08–2.22)0.0293
DRB1*0901 DQA1*0301 DQB1*03031.560.820.53 (0.23–1.19)0.1241.00 (0.44–2.28)0.734
DRB1*1601 DQA1*0102 DQB1*05022.000.990.49 (0.23–1.02)0.05550.93 (0.44–1.96)0.665
DRB1*0401 DQA1*0301 DQB1*03013.901.400.35 (0.20–0.63)4 × 10−460.65 (0.36–1.20)0.176
DRB1*0701 DQA1*0201 DQB1*020110.103.500.32 (0.22–0.46)2 × 10−970.58 (0.38–0.87)0.0157
  • Data are %.

  • * The protective haplotypes excluded are DRB1*150x DQB1*060x; all DRB1*11, -*12, -*13, and -*14 haplotypes with DQB1*0301; DRB1*140x DQB1*050x; and DRB1*0701 DQB1*0303 haplotypes.