TABLE 5

Amino acid differences between closely related DR-DQ haplotypes that differ in type 1 diabetes risk

DRB1*1301-DQA1–0103-DQB1*0603 (OR 0.13)vs.DRB1*1302-DQA1*0102-DQB1*0604 (OR 0.87)
    DRB1 Val-86Gly-86
    DQA1 Arg-41Lys-41
    DQB1 Asp-57, Gly-70, Ala-86Val-57, Arg-70, Gly-86
DRB1*0401-DQA1*0301g-DQB1*0302 (OR 8.39)vs.DQB1*0404-DQA1*0301g-DQB1*0302 (OR 1.59)
    DRB1 Lys-71, Gly-86Arg-71, Val-86
DRB1*1502-DQA1*0101g-DQB1*0501 (OR 0.08)vs.DRB1*1502-DQA1*0102-DQB1*0502 (OR 1.34)
    DQA1 Glu-34Gln-34
    DQB1 Val-57Ser-57