TABLE 2

MAFs of the 14 tSNPs (genotyped at stage II) in the UCP2-UCP3 gene cluster

dbSNP IDFunction annotation*Major/minor alleleMAF (%)Pheterogeneity
Caucasian AmericanAfrican AmericanAsian AmericanHispanic AmericanCombined
n9687323031952,198
rs637028T/G17.439.816.117.125.1<0.0001
rs653263His93HisC/T54.420.345.150.641.0<0.0001
rs622064A/C22.636.532.928.429.2<0.0001
rs2306820T/C30.019.636.720.426.3<0.0001
rs673494C/T38.363.743.545.448.4<0.0001
rs655717C/T54.222.249.352.742.4<0.0001
rs643064G/A13.840.112.625.323.6<0.0001
rs660339Ala55ValC/T39.643.443.845.741.90.0416
rs659366−866 G/AG/A35.442.741.446.739.6<0.0001
rs591758C/G62.225.455.753.448.0<0.0001
rs668514C/T22.527.531.921.025.4<0.0001
rs647126G/A50.123.447.350.640.4<0.0001
rs1800006Tyr99TyrT/C24.159.119.226.735.6<0.0001
rs1800849−55 C/TC/T22.613.715.027.618.9<0.0001
  • * Provided only for coding SNPs (amino acid residues for the two alleles) and for SNPs in the 5′ flanking region (the nucleotide positions relative to the transcription start sites in the promoter regions are indicated).

  • MAF was estimated in the control subjects only.

  • P value was estimated based on a χ2 test (3 d.f.) for genotype distribution across the four ethnicities.