TABLE 1

The type 1 diabetes–associated 12q13 SNPs in two independent cohorts

SNP	Minor allele	Frequency	Informative families*	S†	E(S)‡	Var(S)§	Z	P
Consortium set
rs773107	G	0.322	217	329	290	208	2.73	0.006400
rs10876864	G	0.417	226	395	350	229	2.98	0.002885
rs1701704	C	0.346	216	341	296	211	3.09	0.002019
Canadian set
rs773107	G	0.339	200	180	160	75	2.37	0.017736
rs10876864	G	0.452	212	210	191	87	2.09	0.036293
rs1701704	C	0.357	216	189	169	81	2.22	0.026268
Combined
rs773107	G	0.329	417	509	449	283	3.56	0.000374
rs10876864	G	0.432	438	605	540	316	3.64	0.000278
rs1701704	C	0.350	432	530	465	292	3.80	0.000148

* Number of nuclear families informative for (with a non-zero contribution to) FBAT analysis.
† Observed allele number in the affected offspring.
‡ Expected allele number in the affected offspring.
§ Variance of allele distribution among the affected offspring.