TABLE 1

The type 1 diabetes–associated 12q13 SNPs in two independent cohorts

SNPMinor alleleFrequencyInformative families*SE(S)Var(S)§ZP
Consortium set
    rs773107G0.3222173292902082.730.006400
    rs10876864G0.4172263953502292.980.002885
    rs1701704C0.3462163412962113.090.002019
Canadian set
    rs773107G0.339200180160752.370.017736
    rs10876864G0.452212210191872.090.036293
    rs1701704C0.357216189169812.220.026268
Combined
    rs773107G0.3294175094492833.560.000374
    rs10876864G0.4324386055403163.640.000278
    rs1701704C0.3504325304652923.800.000148
  • * Number of nuclear families informative for (with a non-zero contribution to) FBAT analysis.

  • Observed allele number in the affected offspring.

  • Expected allele number in the affected offspring.

  • § Variance of allele distribution among the affected offspring.