Table 3

DNA damage 8-OHdG according to PPARGC1A genotypes

GenotypenDamage (ng/μg)P valueAdjusted P value*
m9722AA + AC309164.8 ± 6.80.7560.705
CC622167.0 ± 5.9
m1668AA + AG427172.1 ± 6.10.0100.008
GG506159.0 ± 6.3
i5378GG320167.0 ± 6.50.8500.829
GT423164.8 ± 6.4
TT192168.0 ± 7.5
i15867CC669166.6 ± 5.90.1230.104
CT + TT272159.2 ± 6.9
i27289AA356164.3 ± 6.60.7390.704
AG437167.1 ± 6.2
GG147165.1 ± 7.8
i55301AA355173.0 ± 6.30.0120.014
AG + GG581160.0 ± 6.0
G482SCC473163.1 ± 6.40.1030.109
CT384168.7 ± 6.5
TT77181.9 ± 9.7
T612MAA + AG112156.4 ± 8.60.1140.138
GG826167.5 ± 5.8
3U4898AA + AG79150.9 ± 9.60.0300.034
GG866167.9 ± 5.8
  • Data are means ± SE. All means and P values calculated by ANCOVA using general linear models and adjusted for age, sex, BMI, smoking, alcohol use, physical activity, depression medication, and population admixture. n, sample size.

  • * P values were calculated adjusted for additional covariates: type 2 diabetes and CVD.