Table 4

Association between PPARGC1A haplotypes and urinary 8-OHdG levels

Haplotype*FrequencyCoefficient βSEP value
G-T-G-C-G-G0.040.001.420.998
A-C-A-C-G-G0.081.910.890.032
A-C-A-T-G-G0.08−0.070.930.941
A-C-G-C-G-G0.08−0.080.930.934
A-C-G-T-G-G0.015.172.540.042
G-C-A-C-G-G0.210.750.580.199
G-C-A-T-G-G0.140.690.700.324
G-C-G-C-A-G0.02−0.052.330.983
G-C-G-C-G-G0.190.150.630.820
G-C-G-T-G-G0.03−2.901.980.144
G-T-A-C-G-G0.05−2.541.140.027
G-T-A-T-G-G0.062.361.010.020
  • * The six SNPs in haplotypes were arranged in the order of m1668, i15867, i55301, G482S, T612M, and 3U4898.

  • Haplotype frequencies were estimated using the expectation-maximization algorithm (36).

  • Coefficients, SE, and P values were estimated based on haplotype trend regression analysis implemented in HelixTree program while adjusted for the same set of covariates as in Table 3. These haplotypes showed global association with DNA damage at P = 0.009 after permutation correction for multiple tests.