TABLE 1

Mean ± SD change from baseline test scores and effect of glycemia condition and glycemia-awareness interaction

Normal awarenessImpaired awarenessAll subjects combined
EuglycemiaHypoglycemiaPη2EuglycemiaHypoglycemiaPη2EuglycemiaHypoglycemiaEffect of euglycemia/ hypoglycemiaGlycemia-awareness interaction
Pη2Pη2
CRT Exp1−8.7 ± 30.351.2 ± 35.9<0.0010.7625.7 ± 39.434.1 ± 44.90.1240.161−2.3 ± 34.943.6 ± 40.5<0.00010.4350.0870.089
CRT Exp2−14.6 ± 53.668.2 ± 51.8<0.0010.6907.9 ± 39.044.2 ± 54.70.0920.189−4.6 ± 48.457.2 ± 53.8<0.00010.4590.0450.124
CRT Rec1−0.6 ± 57.820.0 ± 45.40.1690.102−3.4 ± 51.913.1 ± 36.80.2830.082−1.9 ± 54.516.9 ± 41.40.0840.0900.8480.001
CRT Rec2−4.5 ± 50.838.7 ± 60.80.0020.409−18.3 ± 66.718.6 ± 23.30.1360.163−10.6 ± 57.730.1 ± 48.90.0020.2640.6720.006
CRT Rec3−15.2 ± 42.023.2 ± 73.50.0050.36014.5 ± 44.420.3 ± 42.50.6960.011−2.0 ± 45.021.9 ± 60.90.0240.1490.0890.088
CRT Rec4−3.8 ± 53.228.0 ± 62.20.0100.31315.5 ± 46.120.4 ± 40.30.7150.0104.8 ± 50.424.6 ± 52.90.0400.1250.1280.071
CRT Rec52.2 ± 47.019.5 ± 44.40.0750.16613.8 ± 49.08.3 ± 44.00.7360.0087.3 ± 47.514.5 ± 43.90.5010.0140.2010.051
CRT Rec6−15.4 ± 55.48.6 ± 50.10.030.23717.4 ± 60.118.1 ± 39.90.9740.000−0.8 ± 59.112.8 ± 45.50.2310.0440.2550.040
CRT Rec7−9.6 ± 51.310.7 ± 59.70.1680.10925.1 ± 57.05.6 ± 43.20.2510.0935.8 ± 55.98.3 ± 52.10.934<0.00010.0730.100
DSST Exp18.1 ± 5.3−6.1 ± 11.0<0.0010.6645.6 ± 5.71.1 ± 9.10.0820.2017.0 ± 5.5−2.9 ± 10.7<0.0010.4810.0090.195
DSST Exp212.2 ± 6.0−0.9 ± 10.2<0.0010.65215.6 ± 8.78.7 ± 11.40.0410.26613.7 ± 7.43.4 ± 11.6<0.0010.4740.1060.080
DSST Rec111.5 ± 8.09.0 ± 7.90.3500.04917.2 ± 10.112.6 ± 11.30.1760.12714.0 ± 9.310.6 ± 9.60.0920.0860.6050.008
DSST Rec213.8 ± 9.011.3 ± 9.10.3330.05219.6 ± 13.115.3 ± 10.70.1980.11516.4 ± 11.213.1 ± 9.90.0970.0840.6330.007
DSST Rec313.8 ± 9.511.9 ± 10.50.4610.03120.6 ± 13.319.3 ± 12.80.7200.00916.8 ± 11.715.2 ± 12.00.4540.0180.8770.001
DSST Rec418.3 ± 7.913.8 ± 16.20.1870.09522.3 ± 14.718.9 ± 12.60.2800.08320.1 ± 11.416.0 ± 14.70.0930.0860.8180.002
DSST Rec517.8 ± 8.316.5 ± 11.40.6830.00924.5 ± 15.021.2 ± 12.40.3120.07320.8 ± 12.118.6 ± 11.90.3190.0310.6730.006
DSST Rec618.5 ± 7.919.4 ± 11.00.7860.00424.4 ± 14.620.5 ± 10.30.1920.11821.1 ± 11.619.9 ± 10.60.4850.0150.2780.037
DSST Rec717.8 ± 11.419.9 ± 11.60.5320.02322.7 ± 15.221.3 ± 11.50.6740.01320.0 ± 13.120.5 ± 11.40.8410.0010.4600.018
TMB Exp11.9 ± 7.07.8 ± 10.50.0260.2592.0 ± 12.911.4 ± 18.90.1950.1481.9 ± 9.99.4 ± 14.40.0420.1350.2410.047
TMB Exp26.3 ± 10.414.6 ± 18.10.0250.263−0.1 ± 10.910.5 ± 12.40.0530.3003.6 ± 10.912.8 ± 15.80.0030.2780.7720.003
TMB Rec11.8 ± 8.94.4 ± 10.20.1740.1062.6 ± 9.77.9 ± 10.00.080.2172.2 ± 9.16.0 ± 10.10.0240.1580.6080.009
TMB Rec23.6 ± 8.12.1 ± 9.60.7650.0053.0 ± 13.211.5 ± 17.60.2500.1093.3 ± 10.56.2 ± 14.20.2510.0450.1730.063
TMB Rec31.9 ± 5.70.4 ± 6.30.5620.0202.4 ± 13.90.9 ± 9.30.6210.0192.1 ± 10.00.6 ± 7.70.4810.0170.7120.005
TMB Rec4−3.5 ± 8.4−5.4 ± 9.20.8400.020−7.0 ± 13.9−2.9 ± 12.90.4490.045−5.0 ± 11.1−4.3 ± 10.90.5220.0140.4060.023
TMB Rec5−2.6 ± 9.4−5.1 ± 8.20.5800.018−3.7 ± 19.7−4.8 ± 11.90.9990.000−3.1 ± 14.6−5.0 ± 9.90.8480.0010.8460.001
TMB Rec60.8 ± 5.2−4.1 ± 8.10.0870.1720.2 ± 13.11.9 ± 11.50.8410.0030.5 ± 9.4−1.4 ± 10.10.5940.0100.3530.030
TMB Rec7−0.6 ± 8.0−5.3 ± 9.70.2900.0701.0 ± 14.0−0.6 ± 8.00.6710.0140.1 ± 10.9−3.2 ± 0.10.3280.0330.8090.002
  • CRT is in milliseconds, and TMB is in seconds. DSST score is the number of symbols identified in 2 min. Boldface indicates significant differences. Exp, experimental phase; Rec, recovery.