TABLE 1

Phenotypes of L-Stat3−/− and littermate controls*

Stat3+/+Stat3+/+;CreStatT3f/+;CreStat3f/f;Cre
Body weight (g)24.88 ± 1.6424.14 ± 1.6123.99 ± 1.5924.34 ± 1.67
Fat mass (g)4.27 ± 0.344.15 ± 0.294.12 ± 0.314.25 ± 0.36
Lean mass (g)19.51 ± 0.9718.98 ± 0.9218.96 ± 0.9119.28 ± 0.98
% Body fat15.12 ± 0.7715.25 ± 0.8315.26 ± 0.7415.54 ± 0.81
Blood glucose (mg/dl)
    Fasting106.7 ± 15.8107.3 ± 15.6104.7 ± 14.9119.6 ± 16.1
    Feeding117.8 ± 17.1112.7 ± 16.3116.7 ± 16.9121.9 ± 18.4
Serum insulin (ng/dl)
    Fasting0.51 ± 0.380.52 ± 0.320.48 ± 0.290.45 ± 0.17
    Feeding0.64 ± 0.450.58 ± 0.370.46 ± 0.280.49 ± 0.14
HOMA-IR54.42 ± 6.0055.80 ± 4.9950.26 ± 4.3253.8 ± 2.73
Serum leptin (ng/ml)7.06 ± 1.396.98 ± 1.377.15 ± 1.4810.41 ± 3.52
  • Data are means ± SD. n = 4–6 for each group.

  • *

    * Male mice measured during 8–12 weeks of age. HOMA-IR, homeostasis model assessment of insulin resistance.