TABLE 3

Multiple linear regression analysis of HOMA-IR and fasting plasma insulin levels at the 10- to 11-year follow-up

Independent variables from baseline in the modelDependent variables
Loge (10-year HOMA-IR)
Loge (10-year fasting plasma insulin level)
ββ′PModel R2ββ′PModel R2
Model 1
    Intra-abdominal fat area0.002720.2370.0020.2890.002770.2580.0010.284
    Abdomen subcutaneous fat area0.000520.0760.2560.000340.0520.441
    HOMA-IR0.124500.378<0.001
    Fasting plasma insulin0.004550.357<0.001
    Incremental insulin response0.000170.0140.7990.000330.0280.614
    2-h plasma glucose−0.03071−0.0950.072−0.02639−0.0870.104
    Age−0.00261−0.0610.281−0.00407−0.1010.083
    Female sex−0.08949−0.0890.158−0.04686−0.0500.439
Model 2: Same variables as model 1, except total subcutaneous fat area is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area0.002840.2480.0010.2880.002870.267<0.0010.265
    Total subcutaneous fat area0.000180.0620.3890.000110.039
    HOMA-IR0.125670.381<0.001
    Fasting plasma insulin0.004600.361<0.001
Model 3: Same variables as model 1, except total fat area is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area0.002660.2320.0060.2880.002760.2570.0030.265
    Total fat area0.000180.0690.3890.000110.0430.593
    HOMA-IR0.125670.381<0.001
    Fasting plasma insulin0.004600.361<0.001
Model 4: Same variables as model 1, except BMI is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area0.002450.2140.0060.2920.002540.2360.0030.267
    Body mass index0.017530.1070.1280.012600.0820.248
    HOMA IR0.122730.372<0.001
    Fasting plasma insulin0.004490.352<0.001
Model 5: Same variables as model 1, except waist circumference is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area0.002420.2110.0090.2910.002530.2350.0040.267
    Waist circumference0.006360.1040.1590.004540.0790.291
    HOMA-IR0.123020.373<0.001
    Fasting plasma insulin0.004490.352<0.001
  • Loge denotes natural logarithm. β and β′ denotes regression coefficient and standardized regression coefficient, respectively.

  • *

    * Incremental insulin response, 2-h plasma glucose, age, and female sex were not significant in any model.