TABLE 4

Multiple linear regression analysis of the Matsuda index and AUC of insulin levels at the 10- to 11-year follow-up

Independent variables from baseline in the modelDependent variables
Loge (10-year Matsuda index)
Loge (10-year AUC insulin)
ββ′PModel R2ββ′PModel R2
Model 1
    Intra-abdominal fat area−0.00204−0.1930.0090.3310.002720.2520.0010.253
    Abdomen subcutaneous fat area−0.00052−0.0820.195−0.00033−0.0510.447
    Matsuda index0.034090.412<0.001
    AUC insulin0.003160.244<0.001
    Incremental insulin response−0.00097−0.0820.1330.002890.240<0.001
    2-h plasma glucose0.028700.0950.073−0.01288−0.0420.440
    Age−0.00009−0.0020.9680.001270.0310.580
    Female sex0.111600.1210.050−0.05903−0.0630.333
Model 2: Same variables as model 1, except total subcutaneous fat area is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area−0.00220−0.2080.0050.3290.002900.269<0.0010.255
    Total subcutaneous fat area−0.00016−0.0610.372−0.00024−0.0880.226
    Matsuda index0.034390.415<0.001
    AUC insulin0.003290.254<0.001
    Incremental insulin response−0.00096−0.0820.1370.002870.239<0.001
Model 3: Same variables as model 1, except total fat area is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area−0.00203−0.1920.0210.3290.003140.2920.0010.255
    Total fat area−0.00016−0.0670.372−0.00024−0.0980.226
    Matsuda index0.034390.415<0.001
    AUC insulin0.003290.254<0.001
    Incremental insulin response−0.00096−0.0820.1370.002870.239<0.001
Model 4: Same variables as model 1, except BMI is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area−0.00197−0.1860.0170.3310.003080.286<0.0010.256
    BMI−0.01211−0.0800.223−0.01469−0.0960.171
    Matsuda index0.034700.419<0.001
    AUC insulin0.003170.244<0.001
    Incremental insulin response−0.00099−0.0840.1250.002870.239<0.001
Model 5: Same variables as model 1, except waist circumference is substituted for abdomen subcutaneous fat area*
    Intra-abdominal fat area−0.00190−0.1800.0240.3310.002900.2690.0010.254
    Waist circumference−0.00491−0.0870.21−0.00386−0.0670.362
    Matsuda index0.034230.413<0.001
    AUC insulin0.003160.244<0.001
    Incremental insulin response−0.00100−0.0850.1220.002880.239<0.001
  • Loge denotes natural logarithm. β and β′ denotes regression coefficient and standardized regression coefficient, respectively.

  • *

    * 2-h plasma glucose, age, and female sex were not significant in any model.