TABLE 1

Immunoreactivities of seven IA-2 constructs in 177 GADA+ LADA patients

FragmentIA-2 COOH-terminal domains
IA-2 middle domains
IA-2 constructs utilized in international screenings
IA-2(761–964)IA-2PTP (687–979)IA-2(256–760)IA-2JM (601–630)IA-2IC (605–979)IA-2FL (1–979)IA-2BDC (256–556:630–979)
% A+9.611.329.4*9.619.818.113.0
n A+ (N = 177)17205217353223
  • *

    * P < 0.0001 vs. IA-2(761–964), IA-2PTP, and IA-2JM; P = 0.048 vs. IA-2IC; P = 0.017 vs. IA-2FL; P < 0.002 vs. IA-2BDC.

  • P = 0.01 vs. IA-2(761–964) and IA-2JM; P = 0.039 vs. IA-2PTP.

  • P = 0.03 vs. IA-2(761–964) and IA-2JM.