TABLE 5

Frequency of HLA class II in LADA patients according to pattern of autoantibody positivity

nHigh riskModerate riskLow risk
Type 2 diabetic patients: GADA and IA-2(256–760)A641.6 (1)9.2 (6)89.2 (57)
Autoimmune patients: GADA+429.5 (4)21.5 (9)69.0 (29)
Autoimmune patients: IA-2(256–760)A+362.8 (1)22.2 (8)75.0 (27)
  • Data are n (%). High risk: DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 genotype (DRB1*04 different from 0403, 06, 11). Moderate risk: DRB1*04-DQB1*0302/DRB1*04-DQB1*0302, DRB1*03-DQB1*0201/DRB1*03-DQB1*0201, DRB1*04-DQB1*0302/X and DRB1*03/X (X different from DRB1*03, DRB1*04-DQB1*0302; DRB1*04 not 0403, 06, 11, or DQB1*0602/03) genotypes. Low risk: other genotypes. P < 0.05 by χ2 2 × 2 (high and moderate vs. low-risk HLA genotypes) for type 2 diabetic GADA and IA-2(256–760)A patients vs. autoimmune GADA+ and IA-2(256–760)A+ patients.