TABLE 3

Reported antigenic T-cell peptides on GAD65 restricted by HLA DR*0401

Epitope position			T-cell epitopes*	Reactive peptides
T1	116–130	`MNILLQYVVKSFDRS`	115–127†
		`VD---N--R-T----`	116–130‡
T2	271–286	`PRLIAFTSEHSHFSL`	274–286†
		`-K-VL----Q--Y-L`	266–280‡
			271–285‡
			276–290‡
T3	481–495	`LYNIIKNREGYEMVF`	481–495‡
		`--AK-----EF----`
T4	511–525	`PSRLTLEDNEERMSR`	511–525‡
		`Q---GVP-SPQ-REK`
T5	551–585	`GDKVNFFRMVISNPAA`	551–565‡
		`---A---N--------`	556–570‡
		`THQDIDFLIEEIERLGQDL`	566–580‡
		`--QS---------------`	553–572§
			555–567†§
			569–585§
			554–570†

*
* Sequence of T-cell epitopes in GAD65 and below the corresponding sequence of GAD67 showing differences; bold sequences indicate reported core immunogenic sequences, alternate immunogenic sequences are underlined.
†
† Wicker et al. (22).
‡
‡ Patel et al. (20).
§
§ Nepom et al. (21).