TABLE 3

Reported antigenic T-cell peptides on GAD65 restricted by HLA DR*0401

Epitope positionT-cell epitopes*Reactive peptides
T1116–130MNILLQYVVKSFDRS115–127
VD---N--R-T----116–130
T2271–286PRLIAFTSEHSHFSL274–286
-K-VL----Q--Y-L266–280
271–285
276–290
T3481–495LYNIIKNREGYEMVF481–495
--AK-----EF----
T4511–525PSRLTLEDNEERMSR511–525
Q---GVP-SPQ-REK
T5551–585GDKVNFFRMVISNPAA551–565
---A---N--------556–570
THQDIDFLIEEIERLGQDL566–580
--QS---------------553–572§
555–567§
569–585§
554–570
  • *

    * Sequence of T-cell epitopes in GAD65 and below the corresponding sequence of GAD67 showing differences; bold sequences indicate reported core immunogenic sequences, alternate immunogenic sequences are underlined.

  • Wicker et al. (22).

  • Patel et al. (20).

  • §

    § Nepom et al. (21).