TABLE 3

Anthropometric and metabolic characteristics of middle-aged glucose-tolerant white Danish subjects stratified according to AHSG Thr248Met and IVS6+98C>T genotype

Thr248Met (n = 4,455)
IVS6+98C>T (n = 4,358)
CCCTTTP (Pcorr)CCCTTTP (Pcorr)
n (men/women)1,865 (893/972)2,033 (913/1,120)557 (266/291)1,226 (580/646)2,145 (980/1,165)987 (456/531)
Age (years)45 ± 845 ± 846 ± 845 ± 845 ± 846 ± 8
BMI (kg/m2)25.4 ± 3.925.6 ± 4.325.3 ± 3.90.725.5 ± 4.025.5 ± 4.225.5 ± 4.10.7
Waist-to-hip ratio0.84 ± 0.080.84 ± 0.080.85 ± 0.080.80.84 ± 0.080.84 ± 0.080.84 ± 0.080.5
Plasma glucose (mmol/l)
    Fasting5.3 ± 0.45.3 ± 0.45.3 ± 0.40.45.3 ± 0.45.3 ± 0.45.3 ± 0.40.4
    30 min8.2 ± 1.68.2 ± 1.58.1 ± 1.50.28.3 ± 1.68.2 ± 1.58.1 ± 1.50.03 (0.2)
    120 min5.5 ± 1.15.5 ± 1.15.4 ± 1.10.55.5 ± 1.15.5 ± 1.15.5 ± 1.10.5
Area under the curve182 ± 103182 ± 100175 ± 950.05185 ± 102181 ± 101177 ± 980.04 (0.2)
Serum insulin (pmol/l)
    Fasting38 ± 2338 ± 2336 ± 250.02 (0.1)38 ± 2338 ± 2337 ± 240.2
    30 min287 ± 183292 ± 175271 ± 1570.09286 ± 183294 ± 183276 ± 1560.1
    120 min168 ± 129172 ± 135158 ± 1220.4167 ± 128173 ± 139162 ± 1190.7
AUC21,068 ± 13,63921,398 ± 13,29319,662 ± 11,8140.04 (0.2)20,986 ± 13,60221,631 ± 13,85520,078 ± 11,6590.09
Insulin resistance (mmol · l−1 · pmol−1 · l−1)
    Homeostasis model assessment of insulin resistance9.0 ± 5.69.0 ± 5.78.6 ± 5.90.01 (0.06)8.9 ± 5.69.0 ± 5.78.7 ± 5.70.2
Fasting serum lipids (mmol/l)
    Triglycerides1.2 ± 0.81.2 ± 1.11.2 ± 0.90.81.2 ± 0.81.2 ± 1.11.2 ± 0.80.6
    Total cholesterol5.4 ± 1.05.4 ± 1.05.4 ± 1.10.55.5 ± 1.05.4 ± 1.05.5 ± 1.10.6
    HDL cholesterol1.5 ± 0.41.5 ± 0.41.4 ± 0.40.31.5 ± 0.41.5 ± 0.41.5 ± 0.40.2
  • Data are means ± SD. Values of serum insulin, values derived from insulin variables, and values of serum triglycerides were logarithmically transformed before statistical analysis. All analyses were made using an additive model. Calculated P values were adjusted for age, sex, and BMI; genotype and sex were considered as fixed factors and age and BMI as covariates. Statistically significant P values were corrected for multiple hypothesis testing (Pcorr). Homeostasis model assessment of insulin resistance was calculated as fasting plasma glucose (mmol/l) multiplied by fasting serum insulin (pmol/l) and divided by 22.5.