TABLE 4

Risk of type 1 diabetes, LADA, and type 2 diabetes, conferred by variants in the INS VNTR, PTPN22, and TCF7L2 genes

Gene/single nucleotide polymorphismRisk genotypeType 1 diabetes
LADA
Type 2 diabetes
OR95% CIPOR95% CIPOR95% CIP
INS VNTR/rs689AA2.31.8–2.9<1 × 10−61.71.2–2.60.004
INS VNTR/rs3842755CC2.21.7–2.81 × 10−61.61.1–2.50.02
PTPN22/rs2476601CT/TT2.31.8–3.1<4 × 10−6*1.71.1–2.70.05*1.51.2–1.90.004*
TCF7L2/rs7903146CT/TT1.51.2–1.90.007*1.41.4–1.7<4 × 10−6*
TCF7L2/rs12255372GT/TT1.51.1–1.90.01*1.31.1–1.50.01*
  • The odds ratios (OR) refer to risk of being diabetic, comparing diabetic groups with the control group, if carrying the particular genotype, using logistic regression analysis with adjustment of BMI, age, sex, and country of origin (where appropriate).

  • *

    * P values corrected for multiple comparisons.