TABLE 4

Potential risks using MSCs

Safety profilingConsideration
Cytogenetic instability of MSCs per SE and support of tumor growthDoes auto-MSC pose equal risk as allo-MSC?
Ectopic MSC differentiationLocal vs. systemic administration?
Fetal calf serum responseUse of cocktails of growth factors or platelet lysate?
Effect of inflammatory molecules released from MSCCould rejected allogeneic MSC cause systemic reactions?
Cell product purificationHighly pure vs. mixed population?