TABLE 2

Measures of β-cell mass in 46 children aged 2 weeks to 21 years, grouped into quintiles

0.2–2.052.06–5.65.7–4.614.7–18.418.5–21.5P
Fractional β-cell area (%)2.6 ± 0.52.1 ± 0.31.7 ± 0.21.3 ± 0.31.3 ± 0.20.023
Mean islet area (μm2)2,589 ± 4764,325 ± 7295,010 ± 5947,493 ± 13939,377 ± 1163< 0.0001
Insulin-positive islet area (μm2)1,533 ± 2312,842 ± 5003,374 ± 4545,030 ± 9006,296 ± 639< 0.0001
Islet density (islets /mm2)27.9 ± 3.518.3 ± 2.611.9 ± 1.06.6 ± 0.77.3 ± 1.20.011
Islet number (millions)0.98 ± 0.171.42 ± 0.251.91 ± 0.431.31 ± 0.201.89 ± 0.500.22
β-Cell nuclear diameter (μm)7.35 ± 0.156.91 ± 0.127.18 ± 0.137.43 ± 0.257.27 ± 0.280.40
β-Cell diameter (μm)11.15 ± 0.1010.77 ± 0.0911.03 ± 0.1011.37 ± 0.1511.19 ± 0.210.0502
  • Data are means ± SE. P values were calculated by ANOVA.