TABLE 2

Hyperinsulinemic-euglycemic clamp data

BL6129FVBDBA
GIR (mmol · kg−1 · min−1)0.30 ± 0.01*0.37 ± 0.020.32 ± 0.020.26 ± 0.01
Insulin (pmol · l−1)338 ± 29§420 ± 37360 ± 34472 ± 59
ΔInsulinClamp-Basal (pmol · l−1)230 ± 26305 ± 45211 ± 17282 ± 47
GIR/insulin (mmol · l−1 · [kg · min−1 · pmol−1]−1) × 10−49.4 ± 0.8§9.2 ± 0.89.4 ± 1.26.4 ± 0.9
GIR/ΔinsulinClamp-Basal (mmol · l−1 · [kg · min−1 · pmol−1]−1) × 10−414.5 ± 1.914.9 ± 2.615.5 ± 1.415.4 ± 4.6
EndoRa (mmol · kg−1 · min−1)−0.03 ± 0.01−0.03 ± 0.020.02 ± 0.01−0.02 ± 0.01
Rd(mmol · kg−1 · min−1)0.27 ± 0.01*§0.33 ± 0.020.34 ± 0.020.24 ± 0.01
Rd/insulin (mmol · L−1 · [kg · min−1 · pmol−1]−1) × 10−48.4 ± 0.7§8.3 ± 0.710.2 ± 0.55.5 ± 0.8
ΔInsulinClamp-Basal/insulin infusion (kg · min · L−1)9.6 ± 1.112.7 ± 1.98.8 ± 0.710.6 ± 2.3
  • Data are means ± SE. Steady-state data during 120-min hyperinsulinemic-euglycemic clamp experiments (24 pmol · kg−1 · min−1 insulin) in chronically catheterized, conscious, 5-h-fasted C57BL/6 (BL6; n = 8), 129X1/Sv (129; n = 9), FVB/N (FVB; n = 7), and DBA/2 (DBA; n = 10) male 12 week-old mice. EndoRa and Rdare determined as described in research design and methods. ΔInsulin Clamp-Basal/insulin infusion is an assessment of insulin clearance. Steady-state values are the mean of five samples taken every 10 min from t = 80–120 min. Comparisons are

  • *

    * BL6 vs. 129,

  • 129 vs. FVB,

  • 129 vs. DBA,

  • §

    § BL6 vs. DBA,

  • FVB vs. DBA, and

  • BL6 vs. FVB, where statistical significance is established at P < 0.05.