TABLE 3

Pancreatic islet mass in four mouse strains

BL6129FVBDBA
Pancreatic insulin content (nmol/g pancreas)25.8 ± 3.1*10.2 ± 1.417.2 ± 0.913.7 ± 1.2
Insulin content in isolated islets (pmol/islet equivalent)10.6 ± 0.5*7.9 ± 0.611.9 ± 0.37.9 ± 0.3
Total islet mass (mg)2.5 ± 0.31.8 ± 0.12.8 ± 0.43.4 ± 0.2
β-Cell mass (mg)2.3 ± 0.31.5 ± 0.12.6 ± 0.43.0 ± 0.2
α-Cell mass (mg)0.20 ± 0.040.23 ± 0.030.18 ± 0.030.38 ± 0.05
  • Data are means ± SE. Total pancreatic insulin content, islet insulin content in isolated islets (normalized for size [islet equivalent]), total islet mass, β-cell mass, and α-cell mass from 12-week-old male C57BL/6 (BL6), 129X1/Sv (129), FVB/N (FVB), and DBA/2 (DBA) mice (n = 4–6 mice/group). Comparisons are

  • *

    * BL6 vs. 129,

  • BL6 vs. FVB,

  • 129 vs. DBA, and

  • § FVB vs. DBA, where statistical significance is established at P < 0.05.