TABLE 1

Plasma measurements of lipids and adipokines in wild-type and α4(Y991A) mice

GenotypeNormal chow diet
High-fat diet
Wild typeY991AWild typeY991A
n65109
Plasma free fatty acids (μmol · l−1 · ml−1)0.71 ± 0.230.44 ± 0.070.89 ± 0.150.61 ± 0.09
Total cholesterol (mg/dl)132.2 ± 5.9130.0 ± 2.7238.7 ± 10.5*203.0 ± 27.9*
Plasma triglycerides (mg/dl)41.2 ± 2.542.7 ± 2.442.4 ± 2.646.6 ± 4.6
MCP-1 (pg/ml)22.0 ± 3.525.67 ± 6.143.25 ± 16.647.0 ± 20.5
Adiponectin (μg · ml−1 · g−1)1.13 ± 0.221.37 ± 0.040.63 ± 0.05*0.68 ± 0.03*
Leptin (pg/ml)3,699 ± 4654,129 ± 72314,038 ± 1,219*10,222 ± 1,878*
IL-6 (pg/ml)0.63 ± 0.010.89 ± 0.091.51 ± 0.681.62 ± 0.44
Resistin (pg/ml)900.3 ± 60.61,104.3 ± 67.41,446.4 ± 108.61,270.8 ± 68.6
TNF-α (pg/ml)2.61 ± 0.282.41 ± 0.313.16 ± 0.273.28 ± 0.49
  • Data are means ± SE. n values per group are indicated.

  • *

    * Significant difference between diet within genotype. None of these parameters were statistically different between genotypes.